Development of ginger-derived extracellular vesicles thermosensitive gel for UVA-induced photodamage of skin
文献类型：期刊论文
| 作者 | Wang, Jinghuang1,5; Ran, Bo1,5; Ma, Wuzhen4; Teng, Yupu1,5; Bello, Mubarak G.2; Chen, Lihua2; Zhang, Jiwen1,2,4,5 ; Sun, Jin5; Ren, Xiaohong3,4; Wu, Li1,2,4,5
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| 刊名 | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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| 出版日期 | 2024-06-01 |
| 卷号 | 96页码:12 |
| 关键词 | Ginger-derived extracellular vesicles Thermosensitive gel UVA-induced photodamage Skin injury |
| ISSN号 | 1773-2247 |
| DOI | 10.1016/j.jddst.2024.105649 |
| 通讯作者 | Sun, Jin(sunjin0529@aliyun.com) ; Ren, Xiaohong(xhren@simm.ac.cn) ; Wu, Li(wuli@simm.ac.cn) |
| 英文摘要 | Due to an increase in outdoor activities, UV radiation exposure has grown recently, leading to an increase in the occurrence of illnesses associated to photodamage. The necessity of developing skin photodamage restoration technology has drawn attention. Herein, a temperature-sensitive gel was designed to load ginger-derived extracellular vesicles (gEVs) for UVA-induced skin inflammatory injury. Traditional medicine has used ginger extracts as natural therapeutic agents, however, no study has looked into how gEVs might be used in drug development or regenerative medicine. The average particle size of gEVs purified by sucrose density gradient centrifugation was 231.20 +/- 25.30 nm, with a tea leaf-like structure and discriminative features. The proliferative and migratory effects of gEVs on epithelial and dermal fibroblast cells were demonstrated. The protective effect of gEVs on in vitro photodamage model was investigated, based on its potent performance in antioxidant capacity that gEVs pretreated cells had a good inhibitory effect on cell viability, UVA-induced apoptosis and reactive oxygen species (ROS). The targeted treatment of specific skin injury sites can be realized by temperaturesensitive gel. The optimal prescription of gel was P407 22.5% and P188 4% screened by gelling temperature and time. The gel with more than 75% water content and 50 mu m porous diameter can provide a transient extracellular matrix for cell adhesion and penetration, and well support the gEVs. Within three days, the 12.5% and 25.0% gEVs@Gel exhibited a mending role by gradually releasing 37.4 +/- 4.5% and 48.7 +/- 2.9% gEVs, respectively. Overall, this study has proposed a novel approach to inflammatory skin healing that may serve as a safe substitute for UVA-induced skin photodamage. |
| WOS关键词 | ULTRAVIOLET-RADIATION ; BLOCK-COPOLYMER ; HYDROGEL ; EXTRACT ; STRESS ; DAMAGE |
| 资助项目 | National Natural Science Foundation of China[82273863] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001296294700001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/312896]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Sun, Jin; Ren, Xiaohong; Wu, Li |
| 作者单位 | 1.Yangtze Delta Drug Adv Res Inst, Nantong 226126, Peoples R China 2.Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China 3.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China 5.Shenyang Pharmaceut Univ, Wuya Coll Innovat, Dept Pharmaceut, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jinghuang,Ran, Bo,Ma, Wuzhen,et al. Development of ginger-derived extracellular vesicles thermosensitive gel for UVA-induced photodamage of skin[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2024,96:12. |
| APA | Wang, Jinghuang.,Ran, Bo.,Ma, Wuzhen.,Teng, Yupu.,Bello, Mubarak G..,...&Wu, Li.(2024).Development of ginger-derived extracellular vesicles thermosensitive gel for UVA-induced photodamage of skin.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,96,12. |
| MLA | Wang, Jinghuang,et al."Development of ginger-derived extracellular vesicles thermosensitive gel for UVA-induced photodamage of skin".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 96(2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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