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A chemo-mechanical model for growth and mechanosensing of focal adhesion

文献类型：期刊论文

作者Xing, Jiashi4,5; Sun, Fuqiang4; Lin, Yuan2,3,4; Gong, Ze1,5
刊名JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
出版日期2024-12-01
卷号193页码:13
关键词Focal adhesion (FA) Mechano-sensing Cellular traction Active contraction
ISSN号0022-5096
DOI10.1016/j.jmps.2024.105863
通讯作者Lin, Yuan(ylin@hku.hk) ; Gong, Ze(gongze@ustc.edu.cn)
英文摘要Focal adhesion (FA), the complex molecular assembly across the lipid membrane, serves as a hub for physical and chemical information exchange between cells and their microenvironment. Interestingly, studies have shown that FAs can grow along the direction of contractile forces generated by actomyosin stress fibers and achieve larger sizes on stiffer substrates. In addition, the cellular traction transmitted to the substrate was observed to reach the maximum near the FA center. However, the biomechanical mechanisms behind these intriguing findings remain unclear. To answer this important question, here we first developed a one-dimensional (1D) chemo-mechanical model of FA where key features like adhesion plaque deformation, active contraction by stress fibers, force-dependent association/dissociation of integrin bonds connecting two surfaces, and substrate compliance have all been considered. Within this formulation, we showed that the rigidity-sensing capability of FAs originates from the deformability of stress fibers while the force-dependent breakage of integrin bonds leads to the appearance of the traction peak at the FA center. Furthermore, by extending the model into three-dimensional as well as incorporating assembly/dis-assembly kinetics of adhesion proteins, we also demonstrated how anisotropic stress/strain field within the adhesion plaque will be induced by the presence of contractile forces which leads to the directional growth of the FA.
分类号一类/力学重要期刊
WOS关键词CELL-ADHESION ; NANOSCALE ARCHITECTURE ; MATRIX ADHESIONS ; MECHANICAL MODEL ; STRESS FIBER ; FORCE ; STIFFNESS ; DYNAMICS ; CONTRACTILITY ; ELASTICITY
资助项目National Natural Science Foundation of China[12202439] ; National Natural Science Foundation of China[12272332] ; USTC Research Funds of the Double First-Class Initiative[YD2090002012] ; Research Grants Council of Hong Kong under the General Research Fund[16205619] ; Research Grants Council of Hong Kong under the General Research Fund[17210520] ; Health@InnoHK program of the Innovation and Technology Commission of the Hong Kong SAR Government
WOS研究方向Materials Science ; Mechanics ; Physics
语种英语
WOS记录号WOS:001318903200001
资助机构National Natural Science Foundation of China ; USTC Research Funds of the Double First-Class Initiative ; Research Grants Council of Hong Kong under the General Research Fund ; Health@InnoHK program of the Innovation and Technology Commission of the Hong Kong SAR Government
其他责任者Lin, Yuan ; Gong, Ze
源URL[http://dspace.imech.ac.cn/handle/311007/96757]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, 15 Beisihuan West Rd, Beijing 100190, Peoples R China
2.Adv Biomed Instrumentat Ctr, Shatin, Hong Kong Sci Pk, Hong Kong, Peoples R China;
3.HKU Shenzhen Inst Res & Innovat, Shenzhen, Guangdong, Peoples R China;
4.Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China;
5.Univ Sci & Technol China, Dept Modern Mech, Key Lab Mech Behav & Design Mat, CAS, Hefei 230027, Anhui, Peoples R China;
推荐引用方式
GB/T 7714		 Xing, Jiashi,Sun, Fuqiang,Lin, Yuan,et al. A chemo-mechanical model for growth and mechanosensing of focal adhesion[J]. JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS,2024,193:13.
APA Xing, Jiashi,Sun, Fuqiang,Lin, Yuan,&Gong, Ze.(2024).A chemo-mechanical model for growth and mechanosensing of focal adhesion.JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS,193,13.
MLA Xing, Jiashi,et al."A chemo-mechanical model for growth and mechanosensing of focal adhesion".JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS 193(2024):13.

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来源：力学研究所

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