Oxytocin modulation of explicit pandemic stigma in men with varying social anxiety levels
文献类型：期刊论文
| 作者 | Wang, Yuwei2,3 ; Zhu, Jiajia2,3; Wang, Jiaxi1; Mu, Yan2,3
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| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2024-12-15 |
| 卷号 | 261页码:12 |
| 关键词 | Stigma Oxytocin Social anxiety Implicit association test COVID-19 |
| ISSN号 | 0028-3908 |
| DOI | 10.1016/j.neuropharm.2024.110140 |
| 通讯作者 | Mu, Yan(muy@psych.ac.cn) |
| 英文摘要 | Objective: Stigma can create divisions within societies, hindering social cohesion and cooperation. Notably, it has significant public health implications, especially during infectious disease outbreaks like COVID-19. However, little is known about the neural and molecular basis of disease-related stigma and their association with individual differences. Methods: To address this gap, we performed a double-blind, placebo-controlled, within-subject design study with 70 males, to investigate the effect of intranasal oxytocin (OT) administration on the explicit and implicit processing of disease-related stigma (i.e., COVID-19 stigma). After self-administrated 24 IU of OT or placebo, participants completed a stigma evaluation task and an Implicit Association Test (IAT) to assess the explicit and implicit processes of stigma evaluation, respectively. Results: The results showed that oxytocin amplified the differences between participants with high and low social anxiety in explicit COVID-19 stigma, with a higher inclination to attribute the stigmatized status of the stigmatized targets (i.e., COVID-19 related group) to personal causes in high social anxiety individuals, but reduced blame towards the stigmatized targets in low social anxiety individuals under oxytocin compared to placebo treatment. Furthermore, oxytocin strengthened the connections between responsibility attribution and the other processes (i.e., emotional, approach motivation, social deviance). While no modulation of oxytocin on implicit stigma emerged, oxytocin did modulate the associations between specific dimensions of explicit stigma (i.e., social deviance and approach motivation) and implicit stigma. Conclusion: In conclusion, these findings demonstrated that intranasal oxytocin administration could temporally impact the explicit cognitive judgment in disease-related stigma but not the implicit aspect; furthermore, it modulated in distinct ways in individuals with different levels of social anxiety. These findings highlight the trait-dependent oxytocin modulation on disease-related stigma, implying that oxytocin is partly involved in the endocrine system of disease-related stigma. By unraveling the molecular basis of stigma and its association with individual traits, such as social anxiety, we can tailor interventions to meet specific needs of different individuals in the future. |
| 收录类别 | SCI |
| WOS关键词 | IMPLICIT ASSOCIATION TEST ; SELF-CONSCIOUSNESS ; FEAR ; VASOPRESSIN ; ATTITUDES ; MODEL ; REACTIVITY ; RESPONSES ; COGNITION ; BELIEFS |
| 资助项目 | National Natural Science Foundation of China[32071016] ; National Natural Science Foundation of China[32271129] ; National Natural Science Foundation of China[32471126] ; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sci-ences[2019000050] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001316713400001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | National Natural Science Foundation of China ; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sci-ences |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48953]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Mu, Yan |
| 作者单位 | 1.Beijing Technol & Business Univ, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yuwei,Zhu, Jiajia,Wang, Jiaxi,et al. Oxytocin modulation of explicit pandemic stigma in men with varying social anxiety levels[J]. NEUROPHARMACOLOGY,2024,261:12. |
| APA | Wang, Yuwei,Zhu, Jiajia,Wang, Jiaxi,&Mu, Yan.(2024).Oxytocin modulation of explicit pandemic stigma in men with varying social anxiety levels.NEUROPHARMACOLOGY,261,12. |
| MLA | Wang, Yuwei,et al."Oxytocin modulation of explicit pandemic stigma in men with varying social anxiety levels".NEUROPHARMACOLOGY 261(2024):12. |
入库方式： OAI收割
来源：心理研究所
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