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Inulin-Based Nanoparticle Modulates Gut Microbiota and Immune Microenvironment for Improving Colorectal Cancer Therapy

文献类型：期刊论文

作者Zhu, Runqi5,6; Yuan, Wenhui5,6; Xia, Anqi5,6; Sun, Xujie5,6; Yan, Wenlu5,6; Wu, Ting4,6; Wang, Guanru6; Li, Yu3,6; Yin, Qi2,5,6; Li, Yaping1,2,4,5,6
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2024-09-02
页码18
关键词colorectal cancer gut microbiota inulin nanoparticle regorafenib
ISSN号1616-301X
DOI10.1002/adfm.202407685
通讯作者Yin, Qi(qyin@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要In consideration of the important influence of gut microbiota on colorectal cancer (CRC) development and host immune system, regulating microbiota and intestinal environment can be an assisting approach to CRC treatment. To remodel tumor microenvironment, the anti-CRC molecular targeting drug regorafenib (REG)-encapsulating nanoparticle (UIRN) is constructed with the amphiphilic inulin-ursodeoxycholic acid conjugate. UIRN increases the intra-tumoral concentration and accumulation time of REG. In the CT26 tumor-bearing mouse model, the relative abundance of probiotics and short-chain fatty acid concentrations in colon are upregulated after treatment with UIRN, with decreased proportion of pro-tumoral bacteria. Combining gut microbiota modulation and the function of REG to induce polarization of tumor-associated macrophages toward the M1-type, UIRN conquers immunosuppression and enhances anti-tumor immunity. UIRN not only efficiently controls tumor progression alone but also exhibits adjuvant effects to chemotherapy and immunotherapy agents. The microbiota-regulating and tumor-suppressing functions of UIRN also work in the colitis-associated CRC model. With good biosafety, UIRN displays hopeful application prospects in CRC therapy. The anti-colorectal cancer (CRC) molecular targeting drug regorafenib-encapsulating nanoparticle is constructed with the amphiphilic inulin-ursodeoxycholic acid conjugate. Combining gut microbiota modulation by the inulin derivative and tumor microenvironment remodeling by regorafenib enhances anti-tumor immunity in CRC mouse models. The nanoparticle also serves as a good synergist of the chemo- or immunotherapy agent like oxaliplatin and the anti-programmed death-1 antibody. image
WOS关键词CHAIN FATTY-ACIDS ; TYROSINE KINASE INHIBITORS ; DIETARY FIBER ; REGORAFENIB ; METABOLISM ; TUMORS
资助项目National Key R&D Program of China[2022YFC3401404] ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[32171315] ; National Natural Science Foundation of China[31930066] ; Natural Science Foundation of Shandong[ZR2019ZD25] ; Shandong Laboratory Program[SYS202205]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:001301950000001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/313020]  
专题新药研究国家重点实验室
通讯作者Yin, Qi; Li, Yaping
作者单位1.Bohai rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Shandong 264000, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
4.Nanjing Med Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211116, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Runqi,Yuan, Wenhui,Xia, Anqi,et al. Inulin-Based Nanoparticle Modulates Gut Microbiota and Immune Microenvironment for Improving Colorectal Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2024:18.
APA Zhu, Runqi.,Yuan, Wenhui.,Xia, Anqi.,Sun, Xujie.,Yan, Wenlu.,...&Li, Yaping.(2024).Inulin-Based Nanoparticle Modulates Gut Microbiota and Immune Microenvironment for Improving Colorectal Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,18.
MLA Zhu, Runqi,et al."Inulin-Based Nanoparticle Modulates Gut Microbiota and Immune Microenvironment for Improving Colorectal Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS (2024):18.

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来源：上海药物研究所

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