A comprehensive pan-cancer analysis revealing the role of ITPRIPL1 as a prognostic and immunological biomarker
文献类型：期刊论文
| 作者 | Duan, Wenyuan3,4; Tian, Wen2,3; Li, Zhongyi3,4; Liu, Yunsong1; Xu, Linping3,4 |
| 刊名 | FRONTIERS IN MOLECULAR BIOSCIENCES
 |
| 出版日期 | 2024-08-15 |
| 卷号 | 11页码:11 |
| 关键词 | ITPRIP1 The Cancer Genome Atlas pan-cancer immune infiltration therapeutic target |
| DOI | 10.3389/fmolb.2024.1452290 |
| 通讯作者 | Liu, Yunsong(liuyunsong0390@zidd.ac.cn) ; Xu, Linping(zlyyxulinping1475@zzu.edu.cn) |
| 英文摘要 | Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein-Like 1 (ITPRIPL1), a single-pass type I membrane protein located in the membrane, functions as an inhibitory ligand of CD3 epsilon. Recent studies have shown that its expression suppresses T cells activation and promote tumor immune evasion. Despite increasing evidence suggesting that ITPRIPL1 plays a significant role in tumor growth, no systematic pan-cancer analysis of ITPRIPL1 has been conducted to date. This study utilized datasets curated from The Cancer Genome Atlas, Genotype Tissue-Expression, and Human Protein Atlas to investigate the relationship between ITPRIPL1 expression and clinical outcomes, immune infiltration, and drug sensitivity across 33 cancer types. We employed multiple methods to assess its prognostic value in pan-cancer, such as univariate Cox regression, survival analysis, and ROC curve analysis and explored the relationship between ITPRIPL1 and tumor mutation burden (TMB), tumor microsatellite instability (MSI), CNV, DNA methylation, immune-related genes, immune cell infiltration, and drug sensitivity to reveal its immunological role. The mRNA expression levels of the ITPRIPL1 gene vary significantly across multiple types of cancer and significantly reduced in breast cancer. Conversely, high ITPRIPL1 expression was associated with a better prognosis in BRCA. Furthermore, the expression of ITPRIPL1 highly correlates with the presence of tumor-infiltrating immune cells and immune checkpoint genes across various types of cancers. Additionally, ITPRIPL1 expression was associated with TMB in 6 cancer types and with MSI in 13 cancer types. High expression of ITPRIPL1 serves as a protective factor in certain cancer types, correlating with longer overall survival in BRCA. Our study further confirms that ITPRIPL1 participates in regulating immune infiltration and affecting the prognosis of patients in pan-cancer. These findings underscore the promising potential of ITPRIPL1 as a therapeutic target for human cancer. |
| WOS关键词 | IMMUNOTHERAPY ; RESOURCE ; CELLS |
| 资助项目 | Henan province Science and Technology Research project[232102310099] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001299550900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313029]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Yunsong; Xu, Linping |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 2.Zhengzhou Univ, Affiliated Canc Hosp, Dept Bone & Soft Tissue Canc, Zhengzhou, Peoples R China 3.Henan Canc Hosp, Zhengzhou, Peoples R China 4.Zhengzhou Univ, Dept Med Res, Affiliated Canc Hosp, Zhengzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Wenyuan,Tian, Wen,Li, Zhongyi,et al. A comprehensive pan-cancer analysis revealing the role of ITPRIPL1 as a prognostic and immunological biomarker[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2024,11:11. |
| APA | Duan, Wenyuan,Tian, Wen,Li, Zhongyi,Liu, Yunsong,&Xu, Linping.(2024).A comprehensive pan-cancer analysis revealing the role of ITPRIPL1 as a prognostic and immunological biomarker.FRONTIERS IN MOLECULAR BIOSCIENCES,11,11. |
| MLA | Duan, Wenyuan,et al."A comprehensive pan-cancer analysis revealing the role of ITPRIPL1 as a prognostic and immunological biomarker".FRONTIERS IN MOLECULAR BIOSCIENCES 11(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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