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Cytotoxic diterpenoids from Croton kongensis inhibiting tumor proliferation and migration

文献类型：期刊论文

作者Zhu, Qiong2; Li, Ying1; Wang, Chenglei2; Yu, Jinhai1,2; Yue, Jianmin1,2; Zhou, Bin1,2
刊名BIOORGANIC CHEMISTRY
出版日期2024-11-01
卷号152页码:15
关键词Croton kongensis ent-Kauranes Structural elucidation Structure-activity relationship Anticancer mechanism
ISSN号0045-2068
DOI10.1016/j.bioorg.2024.107739
通讯作者Yu, Jinhai(jhyu@baridd.ac.cn) ; Yue, Jianmin(jmyue@simm.ac.cn) ; Zhou, Bin(zbbrush@simm.ac.cn)
英文摘要Thirty-two diterpenoids including 18 ent-kauranes (1-6, 1 - 6 , and 12 - 23 ), nine 8,9-seco-ent-kauranes seco-ent-kauranes (7-8, 7 - 8 , and 24 - 30 ), four ent-abietanes (9-10, 9 - 10 , and 31 - 32 ), and one crotofolane (11) 11 ) were isolated from the twigs and leaves of Croton kongensis. . The structures of previously unreported crokokaugenoids A-H (1-8), 1 - 8 ), crokoabiegenoids A-B (9-10), 9 - 10 ), and crokocrotogenoid A (11) 11 ) were determined by spectroscopic data analyses, TDDFT-ECD and GIAO NMR calculations, and X-ray crystallographic studies. All compounds were evaluated for their cytotoxic activity against five human tumor cell lines, and the structure-activity relationships were discussed. Biological tests exhibited that compound 1 possessed strong anti-proliferation activity, arrested cell cycle at G2/M phase, and induced cell apoptosis of MDA-MB-231. The mechanism investigation showed that compound 1 can inhibit tumor proliferation and migration by targeting mitochondria to increase intracellular reactive oxygen species (ROS) and regulating STAT3 and FAK signal pathways. Collectively, these findings supported the great potential of compound 1 as a hopeful anticancer agent.
WOS关键词ENT-KAURANE DITERPENOIDS ; TONKINENSIS ; LIVERWORT
资助项目Shandong Laboratory Program[SYS202205] ; National Natural Science Foundation of China[82322064] ; National Natural Science Foundation of China[82293685] ; Youth Innovation Promotion Association of CAS[2022283]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001301818600001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/313041]  
专题新药研究国家重点实验室
通讯作者Yu, Jinhai; Yue, Jianmin; Zhou, Bin
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Qiong,Li, Ying,Wang, Chenglei,et al. Cytotoxic diterpenoids from Croton kongensis inhibiting tumor proliferation and migration[J]. BIOORGANIC CHEMISTRY,2024,152:15.
APA Zhu, Qiong,Li, Ying,Wang, Chenglei,Yu, Jinhai,Yue, Jianmin,&Zhou, Bin.(2024).Cytotoxic diterpenoids from Croton kongensis inhibiting tumor proliferation and migration.BIOORGANIC CHEMISTRY,152,15.
MLA Zhu, Qiong,et al."Cytotoxic diterpenoids from Croton kongensis inhibiting tumor proliferation and migration".BIOORGANIC CHEMISTRY 152(2024):15.

入库方式： OAI收割

来源：上海药物研究所

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