中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Enhanced In Vitro Efficacy of Verbascoside in Suppressing Hepatic Stellate Cell Activation via ROS Scavenging with Reverse Microemulsion

文献类型：期刊论文

作者Xiao, Xiao7,8; Yang, Feiyu5,6,8; Huang, Yuling4; Liu, Shaohui7,8; Hu, Zhenhua3,7; Liao, Shanggao5,6,8; Li, Yuanyuan1,2,4,7,8
刊名ANTIOXIDANTS
出版日期2024-08-01
卷号13期号:8页码:18
关键词liver fibrosis verbascoside hepatic stellate cells reverse microemulsion antioxidants
DOI10.3390/antiox13080907
通讯作者Liao, Shanggao(lshangg@163.com) ; Li, Yuanyuan(liyuanyuan@simm.ac.cn)
英文摘要Numerous approaches targeting hepatic stellate cells (HSCs) have emerged as pivotal therapeutic strategies to mitigate liver fibrosis and are currently undergoing clinical trials. The investigation of herbal drugs or isolated natural active compounds is particularly valuable, due to their multifaceted functions and low risk of side effects. Recent studies have hinted at the potential efficacy of verbascoside (VB) in ameliorating renal and lung fibrosis, yet its impact on hepatic fibrosis remains to be elucidated. This study aims to evaluate the potential effects of VB on liver fibrosis by assessing its ability to inhibit HSC activation. VB demonstrated significant efficacy in suppressing the expression of fibrogenic genes in activated LX-2 cells. Additionally, VB inhibited the migration and proliferation of these activated HSCs by scavenging reactive oxygen species (ROS) and downregulating the AMPK pathway. Furthermore, a biosafe reverse microemulsion loaded with VB (VB-ME) was developed to improve VB's instability and low bioavailability. The optimal formulation of VB-ME was meticulously characterized, revealing substantial enhancements in cellular uptake, ROS-scavenging capacity, and the suppression of HSC activation.
WOS关键词ANTIOXIDANT ; MECHANISMS ; STABILITY
资助项目National Natural Science Foundation of China[82104252] ; National Natural Science Foundation of China[32260112] ; Shanghai Pujiang Program[21PJ1415600] ; Guangdong Basic and Applied Basic Research Foundation[2022A1515010491] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2023009]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Food Science & Technology
语种英语
WOS记录号WOS:001304953100001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/313044]  
专题中国科学院上海药物研究所
通讯作者Liao, Shanggao; Li, Yuanyuan
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Sun Yat Sen Univ, Nanfang Coll, Dept Hlth & Nursing, Guangzhou 510970, Guangdong, Peoples R China
4.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China
5.Sch Pharm, Guiyang 550025, Peoples R China
6.Univ Engn Res Ctr Prevent & Treatment Chron Dis Au, Guiyang 550025, Peoples R China
7.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
8.Guizhou Med Univ, Sch Pharm, Guiyang 550025, Peoples R China
推荐引用方式
GB/T 7714		 Xiao, Xiao,Yang, Feiyu,Huang, Yuling,et al. Enhanced In Vitro Efficacy of Verbascoside in Suppressing Hepatic Stellate Cell Activation via ROS Scavenging with Reverse Microemulsion[J]. ANTIOXIDANTS,2024,13(8):18.
APA Xiao, Xiao.,Yang, Feiyu.,Huang, Yuling.,Liu, Shaohui.,Hu, Zhenhua.,...&Li, Yuanyuan.(2024).Enhanced In Vitro Efficacy of Verbascoside in Suppressing Hepatic Stellate Cell Activation via ROS Scavenging with Reverse Microemulsion.ANTIOXIDANTS,13(8),18.
MLA Xiao, Xiao,et al."Enhanced In Vitro Efficacy of Verbascoside in Suppressing Hepatic Stellate Cell Activation via ROS Scavenging with Reverse Microemulsion".ANTIOXIDANTS 13.8(2024):18.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。