Sepsis Biomarkers: Advancements and Clinical Applications-A Narrative Review
文献类型：期刊论文
| 作者 | He, Rong-Rong3; Yue, Guo-Li3; Dong, Mei-Ling1,2; Wang, Jia-Qi1; Cheng, Chen1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2024-08-01 |
| 卷号 | 25期号:16页码:30 |
| 关键词 | sepsis biomarkers diagnosis prognosis clinical applications |
| ISSN号 | 1661-6596 |
| DOI | 10.3390/ijms25169010 |
| 通讯作者 | Cheng, Chen(chengchen@simm.ac.cn) |
| 英文摘要 | Sepsis is now defined as a life-threatening syndrome of organ dysfunction triggered by a dysregulated host response to infection, posing significant challenges in critical care. The main objective of this review is to evaluate the potential of emerging biomarkers for early diagnosis and accurate prognosis in sepsis management, which are pivotal for enhancing patient outcomes. Despite advances in supportive care, traditional biomarkers like C-reactive protein and procalcitonin have limitations, and recent studies have identified novel biomarkers with increased sensitivity and specificity, including circular RNAs, HOXA distal transcript antisense RNA, microRNA-486-5p, protein C, triiodothyronine, and prokineticin 2. These emerging biomarkers hold promising potential for the early detection and prognostication of sepsis. They play a crucial role not only in diagnosis but also in guiding antibiotic therapy and evaluating treatment effectiveness. The introduction of point-of-care testing technologies has brought about a paradigm shift in biomarker application, enabling swift and real-time patient evaluation. Despite these advancements, challenges persist, notably concerning biomarker variability and the lack of standardized thresholds. This review summarizes the latest advancements in sepsis biomarker research, spotlighting the progress and clinical implications. It emphasizes the significance of multi-biomarker strategies and the feasibility of personalized medicine in sepsis management. Further verification of biomarkers on a large scale and their integration into clinical practice are advocated to maximize their efficacy in future sepsis treatment. |
| WOS关键词 | INTERNATIONAL CONSENSUS DEFINITIONS ; CELL-FREE HEMOGLOBIN ; REGULATORY T-CELLS ; C-REACTIVE PROTEIN ; SEPTIC PATIENTS ; EMERGENCY-DEPARTMENT ; POTENTIAL BIOMARKER ; ANTIBIOTIC-THERAPY ; PREDICTIVE-VALUE ; SHOCK |
| 资助项目 | National Natural Science Foundation of China[82074176] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001304795100001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313056]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Chen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Guangdong Pharmaceut Univ, Sch Chinese Mat Med, Guangzhou 510006, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin 301617, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Rong-Rong,Yue, Guo-Li,Dong, Mei-Ling,et al. Sepsis Biomarkers: Advancements and Clinical Applications-A Narrative Review[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25(16):30. |
| APA | He, Rong-Rong,Yue, Guo-Li,Dong, Mei-Ling,Wang, Jia-Qi,&Cheng, Chen.(2024).Sepsis Biomarkers: Advancements and Clinical Applications-A Narrative Review.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(16),30. |
| MLA | He, Rong-Rong,et al."Sepsis Biomarkers: Advancements and Clinical Applications-A Narrative Review".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.16(2024):30. |
入库方式： OAI收割
来源：上海药物研究所
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