Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy
文献类型：期刊论文
| 作者 | Lei, Li9,10; Yuan, Jiali8; Dai, Zhijun8; Xiang, Song8; Tu, Qiuxia8; Cui, Xing7; Zhai, Suzhen8; Chen, Xiaozhong6; He, Zhixu1,2,8; Fang, Boyan5 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2024-09-02 |
| 页码 | 23 |
| 关键词 | antioxidant system engineered nanoregulator ferroptosis labile iron pool Parkinson's disease |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202409329 |
| 通讯作者 | Yu, Haijun(hjyu@simm.ac.cn) ; Tang, Lei(tlei1974@gmc.edu.cn) ; Zhang, Chunlin(zcl@gmc.edu.cn) |
| 英文摘要 | Ferroptosis in neurons is considered one of the key factors that induces Parkinson's disease (PD), which is caused by excessive iron accumulation in the intracellular labile iron pool (LIP). The iron ions released from the LIP lead to the aberrant generation of reactive oxygen species (ROS) to trigger ferroptosis and exacerbate PD progression. Herein, a pioneering design of multifunctional nanoregulator deferoxamine (DFO)-integrated nanosheets (BDPR NSs) is presented that target the LIP to restrict ferroptosis and protect against PD. The BDPR NSs are constructed by incorporating a brain-targeting peptide and DFO into polydopamine-modified black phosphorus nanosheets. These BDPR NSs can sequester free iron ions, thereby ameliorating LIP overload and regulating iron metabolism. Furthermore, the BDPR NSs can decrease lipid peroxidation generation by mitigating ROS accumulation. More importantly, BDPR NSs can specifically accumulate in the mitochondria to suppress ROS generation and decrease mitochondrial iron accumulation. In vivo experiments demonstrated that the BDPR NSs highly efficiently mitigated dopaminergic neuronloss and its associated behavioral disorders by modulating the LIP and inhibiting ferroptosis. Thus, the BDPR-based nanovectors holds promise as a potential avenue for advancing PD therapy. |
| WOS关键词 | REVERSES FUNCTIONAL DEFICITS ; CAENORHABDITIS-ELEGANS ; MITOCHONDRIA ; DEATH ; IDENTIFICATION ; APOPTOSIS ; OVERLOAD ; DELIVERY ; SYSTEM ; MODEL |
| 资助项目 | National Natural Science Foundation of China[82160234] ; National Natural Science Foundation of China[32360241] ; National Natural Science Foundation of China[32270848] ; National Natural Science Foundation of China[U23A20498] ; National Natural Science Foundation of China[32460241] ; Guizhou Provincial Science and Technology Projects[ZK[2023]293] ; Elexible Talents Program of Guizhou Medical University[RN21045] ; Young scientific and technological talents of Guizhou Provincial Department of Education[KY[2022]225] ; Science and technology research project of traditional Chinese medicine and ethnic medicine of Guizhou Province Administration of Traditional Chinese Medicine[QZYY-2024-010] ; Cultivation program of Guizhou Medical University[21NSFCP24] ; National College Students Innovation and Entrepreneurship Training Program[202210660044] ; National College Students Innovation and Entrepreneurship Training Program[S202310660032] ; National College Students Innovation and Entrepreneurship Training Program[S202310660039] ; Institutional Animal Care and Use Committee of Guizhou Medical University[2200002] ; Molecular Medicine Engineering Research Center of Guizhou Medical University ; Laboratory Animal Engineering Technology Center of Guizhou Province ; Key Laboratory of Pathogenesis and Drug Research of Common Chronic Diseases in Guizhou Province |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001302786100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313065]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yu, Haijun; Tang, Lei; Zhang, Chunlin |
| 作者单位 | 1.Guizhou Med Univ, Key Lab Med Mol Biol Guizhou Prov, Guiyang 550004, Peoples R China 2.Guizhou Med Univ, Key Lab Endem & Ethn Dis, Minist Educ, Guiyang 550004, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 5.Capital Med Univ, Beijing Rehabil Hosp, Parkinson Med Ctr, Beijing 100144, Peoples R China 6.Guizhou Med University:, Neurosurg Dept, Affiliated Hosp, Peoples Hosp Guiyang 2, Guiyang 550025, Peoples R China 7.Guizhou Med Univ, Coll Pharm, Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, Guiyang 550025, Peoples R China 8.Guizhou Med Univ, Coll Basic Med Sci, Engn Res Ctr Mol Med, Dept Biol, Guiyang 550025, Peoples R China 9.Guizhou Med Univ, Dept Neurosurg, Affiliated Hosp, Guiyang 550025, Peoples R China 10.Guizhou Med Univ, Coll Basic Med Sci, Engn Res Ctr Mol Med, Dept Chem, Guiyang 550025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Li,Yuan, Jiali,Dai, Zhijun,et al. Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy[J]. ADVANCED MATERIALS,2024:23. |
| APA | Lei, Li.,Yuan, Jiali.,Dai, Zhijun.,Xiang, Song.,Tu, Qiuxia.,...&Zhang, Chunlin.(2024).Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy.ADVANCED MATERIALS,23. |
| MLA | Lei, Li,et al."Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy".ADVANCED MATERIALS (2024):23. |
入库方式： OAI收割
来源：上海药物研究所
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