中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer

文献类型：期刊论文

作者Wang, Yiyu2,3; Sun, Meng3; He, Zhong2,3; Han, Ying3; Song, Yinhong2; Liang, Jianjia3; Wang, Huimin3; Qin, Ye1; Deng, Zhangshuang3
刊名HELIYON
出版日期2024-06-30
卷号10期号:12页码:12
关键词Citrus Polymethoxyflavones Estrogen receptor Ubiquitination Tamoxifen
DOI10.1016/j.heliyon.2024.e33104
通讯作者Qin, Ye(ycqinye@163.com) ; Deng, Zhangshuang(dzs163@163.com)
英文摘要Estrogen receptor-positive (ER+) + ) breast cancer seriously endangers the women's physical and mental health worldwide and ER targeting therapy is vital. Here, we found that a citrus polymethoxyflavones (PMFs)-rich hydrolysate (C-H) and its major components (nobiletin and 3methoxynobiletin) potently degrade ER alpha protein via the ubiquitin-proteasome pathway, thereby impairing the proliferation of ER+ + breast cancer cells. Moreover, our study exhibited that C-H combined with tamoxifen (TAM) inhibited the cell proliferation of ER+ + breast cancer in vitro. . It was further confirmed that C-H decreased tumor growth of ER+ + breast cancer in tumor-bearing 129 mice in vivo and improved the efficacy of tamoxifen. Our study revealed that the citrus PMFs have potential applications as pharmaceutical and healthcare products in breast cancer treatment by targeting ER alpha protein degradation.
WOS关键词ENDOCRINE RESISTANCE ; MECHANISMS ; THERAPY
资助项目National Natural Science Foundation of China[32172194] ; Yichang Applied Basic Research Project[A23-2-003] ; Opening foundation of Tumor Microenvironment and Immunotherapy Key Laboratory of Hubei province in China[2020KZL01]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001298469500001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/313074]  
专题新药研究国家重点实验室
通讯作者Qin, Ye; Deng, Zhangshuang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.China Three Gorges Univ, Coll Basic Med Sci, Hubei Key Lab Tumor Microenvironm & Immunotherapy, Yichang 443002, Peoples R China
3.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yiyu,Sun, Meng,He, Zhong,et al. Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer[J]. HELIYON,2024,10(12):12.
APA Wang, Yiyu.,Sun, Meng.,He, Zhong.,Han, Ying.,Song, Yinhong.,...&Deng, Zhangshuang.(2024).Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer.HELIYON,10(12),12.
MLA Wang, Yiyu,et al."Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer".HELIYON 10.12(2024):12.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。