Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice
文献类型：期刊论文
| 作者 | Ma, Junli6,7; Li, Mingxiao7; Bao, Yiyang7; Huang, Wenjin7; He, Xiaofang7; Hong, Ying5,7; Wei, Wenjing7; Liu, Zekun7; Gao, Xinxin7; Yang, Yang4 |
| 刊名 | PHARMACOLOGICAL RESEARCH
 |
| 出版日期 | 2024-10-01 |
| 卷号 | 208页码:15 |
| 关键词 | aging brain neuro-impairment bile acid gut microbiota |
| ISSN号 | 1043-6618 |
| DOI | 10.1016/j.phrs.2024.107361 |
| 通讯作者 | Sheng, Lili(llsheng@shutcm.edu.cn) ; Li, Houkai(hk_li@shutcm.edu.cn) |
| 英文摘要 | Emerging evidence shows that disrupted gut microbiota-bile acid (BA) axis is critically involved in the development of neurodegenerative diseases. However, the alterations in spatial distribution of BAs among different brain regions that command important functions during aging and their exact roles in aging-related neurodegenerative diseases are poorly understood. Here, we analyzed the BA profiles in cerebral cortex, hippocampus, and hypothalamus of young and natural aging mice of both sexes. The results showed that aging altered brain BA profiles sex- and region- dependently, in which T(3MCA was consistently elevated in aging mice of both sexes, particularly in the hippocampus and hypothalamus. Furthermore, we found that aging accumulated-T(3MCA stimulated microglia inflammation in vitro and shortened the lifespan of C. elegans, as well as behavioral impairment and neuroinflammation in mice. In addition, metagenomic analysis suggested that the accumulation of brain T(3MCA during aging was partially attributed to reduction in BSH-carrying bacteria. Finally, rejuvenation of gut microbiota by co-housing aged mice with young mice restored brain BA homeostasis and improved neurological dysfunctions in natural aging mice. In conclusion, our current study highlighted the potential of improving aging-related neuro-impairment by targeting gut microbiota-brain BA axis. |
| WOS关键词 | DISTRIBUTIONS ; INFLAMMATION ; HIPPOCAMPUS ; IMMUNE |
| 资助项目 | Shanghai Excellent Academic Leaders Program[21XD1403500] ; National Natural Science Foundation of China[U21A20413] ; China Postdoctoral Science Foundation[2023M743661] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001307599200001 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313092]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Sheng, Lili; Li, Houkai |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China 3.Tongji Univ, Shanghai East Hosp, Sch Med, Dept Tradit Chinese Med, Shanghai 200120, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Acad Integrat Med, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Key Lab Nutr Metab & Food Safety, Shanghai 200031, Peoples R China 7.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Junli,Li, Mingxiao,Bao, Yiyang,et al. Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice[J]. PHARMACOLOGICAL RESEARCH,2024,208:15. |
| APA | Ma, Junli.,Li, Mingxiao.,Bao, Yiyang.,Huang, Wenjin.,He, Xiaofang.,...&Li, Houkai.(2024).Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice.PHARMACOLOGICAL RESEARCH,208,15. |
| MLA | Ma, Junli,et al."Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice".PHARMACOLOGICAL RESEARCH 208(2024):15. |
入库方式： OAI收割
来源：上海药物研究所
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