Recent progress in chemoenzymatic synthesis of human glycans
文献类型：期刊论文
| 作者 | Ma, Shengzhou1,2; Gao, Jinhua2; Tian, Yinping2; Wen, Liuqing1,2 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2024-08-22 |
| 页码 | 19 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/d4ob01006j |
| 通讯作者 | Wen, Liuqing(lwen@simm.ac.cn) |
| 英文摘要 | Glycan is an essential cell component that usually exists in either a free form or a glycoconjugated form. Glycosylation affects the regulatory function of glycoconjugates in health and disease development, indicating the key role of glycan in organisms. Because of the complexity and diversity of glycan structures, it is challenging to prepare structurally well-defined glycans, which hinders the investigation of biological functions at the molecular level. Chemoenzymatic synthesis is an attractive approach for preparing complex glycans, because it avoids tedious protecting group manipulations in chemical synthesis and ensures high regio- and stereo-selectivity of glucosides during glycan assembly. Herein, enzymes, such as glycosyltransferases (GTs) and glycosidases (GHs), and sugar donors involved in the chemoenzymatic synthesis of human glycans are initially discussed. Many state-of-the-art chemoenzymatic methodologies are subsequently displayed and summarized to illustrate the development of synthetic human glycans, for example, N- and O-linked glycans, human milk oligosaccharides, and glycosaminoglycans. Thus, we provide an overview of recent chemoenzymatic synthetic designs and applications for synthesizing complex human glycans, along with insights into the limitations and perspectives of the current methods. This work reviewed the recent progress in the chemoenzymatic synthesis of human glycans and provides insights into the limitations and perspectives of the current methods. |
| WOS关键词 | ANTENNARY N-GLYCANS ; PROTEIN GLYCOSYLATION ; ENZYMATIC-SYNTHESIS ; HEPARAN-SULFATE ; GENERAL STRATEGY ; OLIGOSACCHARIDES ; HYALURONAN ; LIBRARY ; SIALYLGLYCOPEPTIDE ; BINDING |
| 资助项目 | National Natural Science Foundation of China[22007092] ; National Natural Science Foundation of China[22307127] ; National Natural Science Foundation of China[22ZR1474000] ; Natural Science Foundation of Shanghai ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001307974900001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313098]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wen, Liuqing |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, State Key Lab Chem Biol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Shengzhou,Gao, Jinhua,Tian, Yinping,et al. Recent progress in chemoenzymatic synthesis of human glycans[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2024:19. |
| APA | Ma, Shengzhou,Gao, Jinhua,Tian, Yinping,&Wen, Liuqing.(2024).Recent progress in chemoenzymatic synthesis of human glycans.ORGANIC & BIOMOLECULAR CHEMISTRY,19. |
| MLA | Ma, Shengzhou,et al."Recent progress in chemoenzymatic synthesis of human glycans".ORGANIC & BIOMOLECULAR CHEMISTRY (2024):19. |
入库方式： OAI收割
来源：上海药物研究所
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