Skeleton Rearranged and Oxygenated ent-Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii
文献类型：期刊论文
| 作者 | Song, Qin-Qin3; Guo, Yue1,2,3; Sun, Peng4; Fan, Yao-Yue1,2,3; Ji, Kai-Long4 |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2024-09-10 |
| 页码 | 8 |
| 关键词 | ent-Rosane diterpenoids Euphorbia milii Structure elucidation Configuration determination Biosynthetic pathway hypothesis Oxidation Biological activity Antiadipogenic activity |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202400749 |
| 通讯作者 | Fan, Yao-Yue(s040500290@126.com) ; Ji, Kai-Long(kl14ji@163.com) |
| 英文摘要 | Five unreported and oxygenated ent-rosane diterpenoids (ent-RDs), Euphomillanols A-E (1-5), were isolated from Euphorbia milii. Among them, compounds 1 and 2 are unprecedented 7/7/6-fused tricyclic 5,10-seco-ent-RDs and possess a unique 11-oxabicyclo[4.4.1]undeca-1(10),5-diene moiety, while 3 is characterized by a 1-methyl-6-oxabicyclo[3.2.1]oct-2-ene motif of ring A. Their structures with absolute configurations were unambiguously determined by the extensive spectroscopic methods, X-ray crystallography, and ECD calculation. Putative biosynthetic pathways for compounds 1-3 are proposed. All compounds exhibited antiadipogenic effects in 3T3-L1 adipocytes, and the most potent compound 4 showed an EC50 value of 3.92 mu mol/L with low cytotoxicity (IC50 > 89.54 mu mol/L). |
| WOS关键词 | ABSOLUTE-CONFIGURATION ; MO-2(OAC)(4) ; OVERWEIGHT ; OBESITY |
| 资助项目 | National Natural Science Foundation of China[82122062] ; Xishuangbanna Tropical Botanical Garden[XTBG-145] ; Chinese Academy of Sciences (CAS) ; Program of CAS Key Laboratory of Tropical Plant Resources and Sustainable Use[20228012802] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001309570400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313269]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Fan, Yao-Yue; Ji, Kai-Long |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, 198 East Binhai Rd, Yantai 264117, Shandong, Peoples R China 4.Chinese Acad Sci, CAS Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, 88 Xuefu Rd, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Qin-Qin,Guo, Yue,Sun, Peng,et al. Skeleton Rearranged and Oxygenated ent-Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii[J]. CHINESE JOURNAL OF CHEMISTRY,2024:8. |
| APA | Song, Qin-Qin,Guo, Yue,Sun, Peng,Fan, Yao-Yue,&Ji, Kai-Long.(2024).Skeleton Rearranged and Oxygenated ent-Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii.CHINESE JOURNAL OF CHEMISTRY,8. |
| MLA | Song, Qin-Qin,et al."Skeleton Rearranged and Oxygenated ent-Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii".CHINESE JOURNAL OF CHEMISTRY (2024):8. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。