MicroRNAs in metabolic dysfunction-associated diseases: Pathogenesis and therapeutic opportunities
文献类型：期刊论文
| 作者 | Ma, Ningning2,3; Tan, Jiaxin1; Chen, Yingfen2,3; Yang, Liu2,3; Li, Man1; He, Yong2,3 |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2024-09-01 |
| 卷号 | 38期号:17页码:21 |
| 关键词 | ALD diabetes MASLD MiRNAs obesity |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.202401464R |
| 通讯作者 | Li, Man(liman121000@shutcm.edu.cn) ; He, Yong(heyong@simm.ac.cn) |
| 英文摘要 | Metabolic dysfunction-associated diseases often refer to various diseases caused by metabolic problems such as glucose and lipid metabolism disorders. With the improvement of living standards, the increasing prevalence of metabolic diseases has become a severe public health problem, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), diabetes and obesity. These diseases are both independent and interdependent, with complex and diverse molecular mechanisms. Therefore, it is urgent to explore the molecular mechanisms and find effective therapeutic targets of these diseases. MicroRNAs (miRNAs) have emerged as key regulators of metabolic homoeostasis due to their multitargets and network regulatory properties within the past few decades. In this review, we discussed the latest progress in the roles of miRNA-mediated regulatory networks in the development and progression of MASLD, ALD, diabetes and obesity. |
| WOS关键词 | NONALCOHOLIC FATTY LIVER ; TYPE-2 DIABETES-MELLITUS ; INSULIN-RESISTANCE ; PROMOTES ADIPOGENESIS ; ADIPOSE-TISSUE ; BETA-CELL ; EXPRESSION ; STRESS ; STEATOSIS ; FIBROSIS |
| 资助项目 | Postdoctoral Fellowship Program of CPSF |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001308963300001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313272]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Man; He, Yong |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Lab Cellular Immun, Shanghai Key Lab Tradit Chinese Med, 528 Zhangheng Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Ningning,Tan, Jiaxin,Chen, Yingfen,et al. MicroRNAs in metabolic dysfunction-associated diseases: Pathogenesis and therapeutic opportunities[J]. FASEB JOURNAL,2024,38(17):21. |
| APA | Ma, Ningning,Tan, Jiaxin,Chen, Yingfen,Yang, Liu,Li, Man,&He, Yong.(2024).MicroRNAs in metabolic dysfunction-associated diseases: Pathogenesis and therapeutic opportunities.FASEB JOURNAL,38(17),21. |
| MLA | Ma, Ningning,et al."MicroRNAs in metabolic dysfunction-associated diseases: Pathogenesis and therapeutic opportunities".FASEB JOURNAL 38.17(2024):21. |
入库方式： OAI收割
来源：上海药物研究所
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