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Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures

文献类型：期刊论文

作者Sun, Chuanxin5; Su, Juan4; Wang, Jiarui3,5; Ding, Kan2,3,4; Chen, Chang1,3,5
刊名FASEB JOURNAL
出版日期2024-09-15
卷号38期号:17页码:17
关键词cold resistance efficacy gut microbiota Lycium barbarum polysaccharide thermogenesis white adipose tissue browning
ISSN号0892-6638
DOI10.1096/fj.202400870R
通讯作者Ding, Kan(dingkan@simm.ac.cn) ; Chen, Chang(changchen@moon.ibp.ac.cn)
英文摘要Traditional Chinese medical literature contains numerous records of many traditional Chinese herbal medicines that exhibit efficacy in enhancing resistance to cold, yet there is a lack of scientific explanation. Lycium barbarum is among the herbal medicines that are explicitly documented to enhance resistance to cold in the "Ben Cao Gang Mu (Compendium of Materia Medica)". Herein, we investigated L. barbarum polysaccharide (LBP)-induced browning of inguinal white adipose tissue (iWAT), energy expenditure and thermogenic function in a long-term (4 months) treatment mouse model. LBP supplementation resulted in a significant reduction in weight and adipocyte size in iWAT, along with increased gut microbiota diversity. Specifically, the levels of Lachnospiraceae, Ruminococcaceae and Bacteroidaceae (short-chain fatty acid-producing bacteria) were elevated, leading to a higher level of short-chain fatty acids (SCFAs) in the caecal content. These effects subsequently triggered the release of glucagon-like peptide-1 (GLP-1) and activated the CREB/PGC1 alpha signaling pathway in iWAT, thereby increasing energy expenditure and enhancing thermogenic function. The antibiotic treatment experiments confirmed that the LBP-mediated gut microbiota participated in the process of iWAT browning. In summary, our findings provide the first scientific explanation and mechanistic insights into the cold resistance of L. barbarum and identify potentially safe natural product supplements for individuals in alpine areas.
WOS关键词CHAIN FATTY-ACIDS ; ADIPOSE-TISSUE ; FRUITS ; L. ; OPTIMIZATION ; ACTIVATION ; STRESS
资助项目Key Research and Development Program of Ningxia[2016BZ05] ; Regional Key Projects of Science and Technology Service Network Plan of the Chinese Academy of Sciences[KFJ-STS-QYZD-181] ; MOST | National Key Research and Development Program of China (NKPs)[2022YFA1303000] ; MOST | National Key Research and Development Program of China (NKPs)[2022YFA1305100] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB39000000]
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
语种英语
WOS记录号WOS:001305639000001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/313275]  
专题新药研究国家重点实验室
通讯作者Ding, Kan; Chen, Chang
作者单位1.Capital Med Univ, Beijing Inst Brain Disorders, Beijing, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, SSIP Healthcare & Med Demonstrat Zone, Zhongshan, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai, Peoples R China
5.Chinese Acad Sci, CAS Ctr Excellence Biomacromolecules, Key Lab Biomacromolecules CAS, Natl Lab Biomacromolecules,Inst Biophys, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Chuanxin,Su, Juan,Wang, Jiarui,et al. Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures[J]. FASEB JOURNAL,2024,38(17):17.
APA Sun, Chuanxin,Su, Juan,Wang, Jiarui,Ding, Kan,&Chen, Chang.(2024).Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures.FASEB JOURNAL,38(17),17.
MLA Sun, Chuanxin,et al."Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures".FASEB JOURNAL 38.17(2024):17.

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来源：上海药物研究所

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