Structural characterization and Bacteroides proliferation promotion activity of a novel homogeneous arabinoglucuronoxylan from Commelina communis L.
文献类型：期刊论文
| 作者 | Wang, Xiaojiang1,2; Lu, Yan2; Li, Meixia1; Xia, Xiao2; Jin, Can1; Ding, Kan1 ; Chen, Daofeng2
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| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 153页码:10 |
| 关键词 | Arabinoglucuronoxylan Human gut Bacteroides strains Short-chain fatty acids 2-Propanediol |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2024.107790 |
| 通讯作者 | Ding, Kan(dingkan@simm.ac.cn) ; Chen, Daofeng(dfchen@shmu.edu.cn) |
| 英文摘要 | Commelina communis L., a functional food and herbal plant in Asia, has been used against obesity, diabetes, and infections for centuries. A growing body of studies has demonstrated that indigestible polysaccharides are significant in obesity management. However, the structures and bioactivities of homogeneous polysaccharides from C. communis remain unclear. This study presented the structural characterization, simulated digestion, and human gut Bacteroides proliferation promotion activity of a novel homogeneous polysaccharide (CCB-3) from C. communis. The results showed that CCB-3 was an arabinoglucuronoxylan, primarily composed of arabinose, galactose, xylose, glucuronic acid (GlcA), and 4-O-methyl GlcA with a molecular weight (Mw) of 58.8 kDa. Following a 6-hour exposure to simulated gastrointestinal fluid, the Mw of CCB-3 remained unchanged, revealing that CCB-3 was an indigestible polysaccharide. Notably, CCB-3 could promote the proliferation of B. thetaiotaomicron, B. ovatus, and B. cellulosilyticus and produce short-chain fatty acids (SCFAs) and 1,2-propanediol. These findings might shed light on the discovery of polysaccharide-based leading compounds from C. communis against obesity. |
| WOS关键词 | CHAIN FATTY-ACIDS ; HETEROXYLAN ; BIOACTIVITY ; DAYFLOWER |
| 资助项目 | National Natural Science Foundation of China[81872977] ; National Key New Drug Creation and Manufacturing Project ; Ministry of Science and Technology of China[2019ZX09735001-002] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001309419000001 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313278]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ding, Kan; Chen, Daofeng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochemistry & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Fudan Univ, Sch Pharm, Dept Nat Med, 826 Zhang Heng Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaojiang,Lu, Yan,Li, Meixia,et al. Structural characterization and Bacteroides proliferation promotion activity of a novel homogeneous arabinoglucuronoxylan from Commelina communis L.[J]. BIOORGANIC CHEMISTRY,2024,153:10. |
| APA | Wang, Xiaojiang.,Lu, Yan.,Li, Meixia.,Xia, Xiao.,Jin, Can.,...&Chen, Daofeng.(2024).Structural characterization and Bacteroides proliferation promotion activity of a novel homogeneous arabinoglucuronoxylan from Commelina communis L..BIOORGANIC CHEMISTRY,153,10. |
| MLA | Wang, Xiaojiang,et al."Structural characterization and Bacteroides proliferation promotion activity of a novel homogeneous arabinoglucuronoxylan from Commelina communis L.".BIOORGANIC CHEMISTRY 153(2024):10. |
入库方式： OAI收割
来源：上海药物研究所
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