Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists
文献类型：期刊论文
| 作者 | Ding, Dong2; Gao, Runing1; Lei, Yujuan2; Liu, Jianing1; Zhou, Chengkai1; Wen, Yu2; Zhou, Shihao2; Guo, Jun2; Li, Tiehai1 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2024-11-15 |
| 卷号 | 278页码:15 |
| 关键词 | TLR4 agonist NOD2 agonist Adjuvant Covalent conjugation Subunit vaccine |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2024.116792 |
| 通讯作者 | Guo, Jun(jguo@ccnu.edu.cn) ; Li, Tiehai(tiehaili@simm.ac.cn) |
| 英文摘要 | Enhancing the efficacy of subunit vaccines relies significantly on the utilization of potent adjuvants, particularly those capable of triggering multiple immune pathways. To achieve synergistic immune augmentation by Toll-like receptor 4 agonist (TLR4a) and nucleotide-binding oligomerization-domain-containing protein 2 agonist (NOD2a), in this work, we conjugated RC529 (TLR4a) and MDP (NOD2a) to give RC529-MDP, and evaluated its adjuvanticity for OVA antigen. Compared to the unconjugated RC529+MDP, RC529-MDP remarkably enhanced innate immune responses with 6.8-fold increase in IL-6 cytokine, and promoted the maturation of antigenpresenting cells (APCs), possibly because of the conjugation of multiple agonists ensuring their delivery to the same cell and activation of various signaling pathways within that cell. Furthermore, RC529-MDP improved OVA-specific antibody response, T cells response and the memory T cells ratio relative to the unconjugated mixture. Therefore, covalently conjugating TLR4 agonist and NOD2 agonist was an effective strategy to enhance immune responses, providing the potential to design and develop more effective vaccines. |
| WOS关键词 | TOLL-LIKE RECEPTORS ; CYTOKINE PRODUCTION ; VACCINE ; ADJUVANT ; LIPOPOLYSACCHARIDE ; RECOGNITION ; MODULATION ; RESPONSES ; CELLS ; LPS |
| 资助项目 | National Natural Science Foundation of China[22177035] ; National Natural Science Foundation of China[22077130] ; National Natural Science Foundation of China[22377134] ; National Natural Science Foundation of China[22477039] ; Shanghai Municipal Science and Technology Major Project ; Fundamental Research Funds for the Central Universities[CCNU22JC007] ; Program of Introducing Talents of Discipline to Universities of China[B17019] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001305474700001 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313281]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Jun; Li, Tiehai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 2.Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Dong,Gao, Runing,Lei, Yujuan,et al. Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2024,278:15. |
| APA | Ding, Dong.,Gao, Runing.,Lei, Yujuan.,Liu, Jianing.,Zhou, Chengkai.,...&Li, Tiehai.(2024).Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,278,15. |
| MLA | Ding, Dong,et al."Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 278(2024):15. |
入库方式： OAI收割
来源：上海药物研究所
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