Structurally intriguing rearranged bicyclogermacrene-type sesquiterpenoid from Aphania oligophylla
文献类型：期刊论文
| 作者 | Zhou, Bin3; Wu, Yan3; Zimbres, Flavia M.1,2; Cassera, Maria B.1,2; Yue, Jian-Min3
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2024-10-25 |
| 卷号 | 150页码:4 |
| 关键词 | Aphania oligophylla Chinese endemic species Sesquiterpenoids X-ray crystallography Biosynthetic pathway Antimalarial tests |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2024.155276 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | An investigation on the aqueous ethanol extract of the powdered twigs of Aphania oligophylla has afforded a skeletal new sesquiterpenoid aphanoid A (1) and one new aromadendrane-type sesquiterpenoid aphanoid B (2), as well as six known sesquiterpenoids (3-8). Their structures including the absolute configurations were characterized based on spectroscopic data analysis and X-ray crystallography. Compound 1 featuring an unprecedented tricyclo[6.3.1.03,5]dodecane scaffold, is likely rearranged from the bicyclogermacrene-type sesquiterpenoid. Among those compounds, 2 at 10 mu L showed moderate antimalarial effect. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001308776200001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313287]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Athens, GA 30602 USA 2.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Wu, Yan,Zimbres, Flavia M.,et al. Structurally intriguing rearranged bicyclogermacrene-type sesquiterpenoid from Aphania oligophylla[J]. TETRAHEDRON LETTERS,2024,150:4. |
| APA | Zhou, Bin,Wu, Yan,Zimbres, Flavia M.,Cassera, Maria B.,&Yue, Jian-Min.(2024).Structurally intriguing rearranged bicyclogermacrene-type sesquiterpenoid from Aphania oligophylla.TETRAHEDRON LETTERS,150,4. |
| MLA | Zhou, Bin,et al."Structurally intriguing rearranged bicyclogermacrene-type sesquiterpenoid from Aphania oligophylla".TETRAHEDRON LETTERS 150(2024):4. |
入库方式： OAI收割
来源：上海药物研究所
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