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Chinese Academy of Sciences Institutional Repositories Grid
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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers

文献类型：期刊论文

作者Dong, Baijun9,10; Xu, Jun-Yu7,8; Huang, Yuqi8; Guo, Jiacheng6; Dong, Qun5; Wang, Yanqing10; Li, Ni6; Liu, Qiuli4; Zhang, Mingya8; Pan, Qiang6
刊名NATURE CANCER
出版日期2024-09-01
卷号5期号:9页码:39
DOI10.1038/s43018-024-00820-2
通讯作者Qin, Jun(qinjun@sibs.ac.cn)
英文摘要Prostate cancer (PCa) exhibits significant geoethnic disparities as reflected by distinct variations in the cancer genome and disease progression. Here, we perform a comprehensive proteogenomic characterization of localized high-risk PCa utilizing paired tumors and nearby tissues from 125 Chinese male patients, with the primary objectives of identifying potential biomarkers, unraveling critical oncogenic events and delineating molecular subtypes with poor prognosis. Our integrated analysis highlights the utility of GOLM1 as a noninvasive serum biomarker. Phosphoproteomics analysis reveals the crucial role of Ser331 phosphorylation on FOXA1 in regulating FOXA1-AR-dependent cistrome. Notably, our proteomic profiling identifies three distinct subtypes, with metabolic immune-desert tumors (S-III) emerging as a particularly aggressive subtype linked to poor prognosis and BCAT2 catabolism-driven PCa progression. In summary, our study provides a comprehensive resource detailing the unique proteomic and phosphoproteomic characteristics of PCa molecular pathogenesis and offering valuable insights for the development of diagnostic and therapeutic strategies. Dong et al. present an integrative proteogenomic analysis of high-risk prostate cancer samples from a cohort of Chinese patients and highlight potential therapeutic vulnerabilities and diagnostic markers.
WOS关键词AMINO-ACID SUPPLEMENTATION ; HEPATOCELLULAR-CARCINOMA ; RADIOFREQUENCY ABLATION ; SIOG GUIDELINES ; CLASS DISCOVERY ; LOCAL TREATMENT ; MULTICENTER ; LANDSCAPE ; GENOME ; TRANSCRIPTOME
资助项目National Natural Science Foundation of China (National Science Foundation of China)[2021YFA1300601] ; National Natural Science Foundation of China (National Science Foundation of China)[2018YFA0902700] ; National Natural Science Foundation of China (National Science Foundation of China)[2020YFE0202200] ; National Key Research and Development Program of China[8245103] ; National Key Research and Development Program of China[82341012] ; National Key Research and Development Program of China[22225702] ; National Key Research and Development Program of China[81825018] ; National Key Research and Development Program of China[82130085] ; National Key Research and Development Program of China[82372698] ; National Key Research and Development Program of China[82372771] ; National Key Research and Development Program of China[92153302] ; National Key Research and Development Program of China[82203495] ; National Key Research and Development Program of China[81821005] ; National Key Research and Development Program of China[32322048] ; National Natural Science Foundation of China Projects[JCYJ-SHFY-2022-007] ; Shanghai Pilot Program for Basic Research-Chinese Academy of Science, Shanghai Branch[22XD1420900] ; Shanghai Academic/Technology Research Leader Program[2019B090904008] ; Guangdong High-level New RD Institute[2021B0909050003] ; Guangdong High-level Innovative Research Institute[22QA1411100] ; Shanghai Rising-Star Program[2021276] ; Youth Innovation Promotion Association CAS[2022QNRC001] ; Young Elite Scientists Sponsorship Program by CAST ; Innovative Research Team of High-Level Local Universities in Shanghai ; Sanofi scholarship program ; Center for High Performance Computing at Shanghai Jiao Tong University
WOS研究方向Oncology
语种英语
WOS记录号WOS:001306563800001
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/313299]  
专题新药研究国家重点实验室
通讯作者Qin, Jun
作者单位1.Jinfeng Lab, Chongqing, Peoples R China
2.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Key Lab Cell Differentiat & Apoptosis, Chinese Minist Educ,Sch Med, Shanghai, Peoples R China
3.Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Sch Med, Shanghai, Peoples R China
4.Army Med Univ, Daping Hosp, Inst Surg Res, Dept Oncol, Chongqing, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Dept Bioinformat & Biostat, Shanghai, Peoples R China
6.Univ Chinese Acad, CAS Key Lab Tissue Microenvironm & Tumor, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Nutr & Hlth,Chinese Acad Sci, Shanghai, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan, Guangdong, Peoples R China
8.Univ Chinese Acad Sci, Shanghai Inst Mat Med, Chinese Acad Sci, State Key Lab Drug Res, Shanghai, Peoples R China
9.Shanghai Univ Med & Hlth Sci, Dept Urol, Jiading Dist Cent Hosp Affiliated, Shanghai, Peoples R China
10.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Urol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Dong, Baijun,Xu, Jun-Yu,Huang, Yuqi,et al. Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers[J]. NATURE CANCER,2024,5(9):39.
APA Dong, Baijun.,Xu, Jun-Yu.,Huang, Yuqi.,Guo, Jiacheng.,Dong, Qun.,...&Qin, Jun.(2024).Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers.NATURE CANCER,5(9),39.
MLA Dong, Baijun,et al."Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers".NATURE CANCER 5.9(2024):39.

入库方式： OAI收割

来源：上海药物研究所

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