Intramolecular through-space NMR spectroscopic effect of steric compression on 1H NMR spectroscopy
文献类型：期刊论文
| 作者 | Zeng, Ziyu3; Qasem, Ashraf M. A.2; Blagbrough, Ian S.1; Woodman, Timothy J.1 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2024-09-09 |
| 页码 | 21 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/d4ob01108b |
| 通讯作者 | Qasem, Ashraf M. A.(aqasem@zu.edu.jo) |
| 英文摘要 | The intramolecular through-space NMR spectroscopic effect of steric compression is related to intramolecular through-space van der Waals repulsion. The electron cloud of a proton can be pushed away by the electron cloud of a nearby proton or functional group. As the electron population of the sterically compressed proton is decreased (therefore deshielded), the chemical shift sharply moves downfield, which may result in ambiguity for the proton signal assignment. Also, the conformation of the local area of the sterically compressed proton can be altered by the steric repulsion, therefore, the coupling constant/coupling pattern of a sterically compressed proton could be influenced. This review summarizes and presents the impacts on the chemical shift and coupling constant by the H-1 NMR spectroscopic effect of steric compression extracted from the reported examples from the 1950s to 2021. |
| WOS关键词 | MAGNETIC-RESONANCE SPECTRA ; CONDENSED BENZENOID HYDROCARBONS ; BUNGAROTOXIN BINDING-SITES ; DES DERIVES POLYCYCLIQUES ; CHEMICAL-SHIFTS ; HALF-CAGE ; NORDITERPENOID ALKALOIDS ; CARACTERE AROMATIQUE ; LA SPECTROGRAPHIE ; TRICYCLIC ANALOGS |
| 资助项目 | University of Bath ; University of Bath |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001309087100001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313308]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Qasem, Ashraf M. A. |
| 作者单位 | 1.Univ Bath, Life Sci, Bath BA2 7AY, England 2.Zarqa Univ, Fac Pharm, Dept Pharmaceut Sci, Zarqa, Jordan 3.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Ziyu,Qasem, Ashraf M. A.,Blagbrough, Ian S.,et al. Intramolecular through-space NMR spectroscopic effect of steric compression on 1H NMR spectroscopy[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2024:21. |
| APA | Zeng, Ziyu,Qasem, Ashraf M. A.,Blagbrough, Ian S.,&Woodman, Timothy J..(2024).Intramolecular through-space NMR spectroscopic effect of steric compression on 1H NMR spectroscopy.ORGANIC & BIOMOLECULAR CHEMISTRY,21. |
| MLA | Zeng, Ziyu,et al."Intramolecular through-space NMR spectroscopic effect of steric compression on 1H NMR spectroscopy".ORGANIC & BIOMOLECULAR CHEMISTRY (2024):21. |
入库方式： OAI收割
来源：上海药物研究所
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