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Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment

文献类型：期刊论文

作者Yan, Wenlu4,5,6; Cao, Ying3,5,6; Yin, Qi2,4,5,6; Li, Yaping1,2,4,5,6
刊名PHARMACEUTICS
出版日期2024-08-01
卷号16期号:8页码:21
关键词biomimetic drug delivery system nucleic acid immunotherapy tumor immunosuppressive microenvironment
DOI10.3390/pharmaceutics16081028
通讯作者Yin, Qi(qyin@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Immunotherapy combats tumors by enhancing the body's immune surveillance and clearance of tumor cells. Various nucleic acid drugs can be used in immunotherapy, such as DNA expressing cytokines, mRNA tumor vaccines, small interfering RNAs (siRNA) knocking down immunosuppressive molecules, and oligonucleotides that can be used as immune adjuvants. Nucleic acid drugs, which are prone to nuclease degradation in the circulation and find it difficult to enter the target cells, typically necessitate developing appropriate vectors for effective in vivo delivery. Biomimetic drug delivery systems, derived from viruses, bacteria, and cells, can protect the cargos from degradation and clearance, and deliver them to the target cells to ensure safety. Moreover, they can activate the immune system through their endogenous activities and active components, thereby improving the efficacy of antitumor immunotherapeutic nucleic acid drugs. In this review, biomimetic nucleic acid delivery systems for relieving a tumor immunosuppressive microenvironment are introduced. Their immune activation mechanisms, including upregulating the proinflammatory cytokines, serving as tumor vaccines, inhibiting immune checkpoints, and modulating intratumoral immune cells, are elaborated. The advantages and disadvantages, as well as possible directions for their clinical translation, are summarized at last.
WOS关键词MESSENGER-RNA ; NONVIRAL VECTORS ; GENE-TRANSFER ; CO-DELIVERY ; CANCER ; VIRUS ; CELLS ; IMMUNOTHERAPY ; NANOPARTICLES ; THERAPIES
资助项目National Key R&D Program of China[2022YFC3401404] ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[32171315] ; National Natural Science Foundation of China[31930066] ; Natural Science Foundation of Shandong[ZR2019ZD25] ; Shandong Laboratory Program[SYS202205]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001305432200001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/313311]  
专题新药研究国家重点实验室
通讯作者Yin, Qi; Li, Yaping
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
3.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Wenlu,Cao, Ying,Yin, Qi,et al. Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment[J]. PHARMACEUTICS,2024,16(8):21.
APA Yan, Wenlu,Cao, Ying,Yin, Qi,&Li, Yaping.(2024).Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment.PHARMACEUTICS,16(8),21.
MLA Yan, Wenlu,et al."Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment".PHARMACEUTICS 16.8(2024):21.

入库方式： OAI收割

来源：上海药物研究所

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