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Multi-omics profiling reveals peripheral blood biomarkers of multiple sclerosis: implications for diagnosis and stratification

文献类型：期刊论文

作者Zhou, Qinming8,9,10,11; Xie, Zuoquan7; He, Lu8,10,11; Sun, Guangqiang6; Meng, Huanyu8,10,11; Luo, Zhiyu6; Feng, Yuan6; Chu, Xingkun6; Li, Liang6; Zhang, Jing6
刊名FRONTIERS IN PHARMACOLOGY
出版日期2024-08-27
卷号15页码:12
关键词multiple sclerosis multi-omics blood immune phenotyping proteomic metabolomic clinically isolated syndrome secondary progressive MS
DOI10.3389/fphar.2024.1458046
通讯作者Hao, Yong(yhao23@126.com) ; Geng, Meiyu(mygeng@simm.ac.cn) ; Zhang, Xiang(zhangxiang1213@hotmail.com) ; Chen, Sheng(mztcs@163.com)
英文摘要Background Multiple sclerosis (MS), a chronic autoimmune disorder marked by demyelination in the central nervous system, is exceptionally uncommon in China, and remains poorly understood in terms of its peripheral blood manifestations.Methods We conducted a cohort study comprising 39 MS patients and 40 normal controls (NC). High-dimensional mass cytometry, protein arrays, and targeted metabolomics were utilized to profile immune subsets, proteins, and metabolites in blood. Differences in multi-omics signatures were scrutinized across varying MS subtypes.Results Immune profiling demonstrated an elevation in various B cell subsets and monocytes, alongside a reduction in dendritic cells among MS patients. Proteomic data revealed a downregulation in neurotrophic and tissue repair proteins. Metabolomic assessment showed a noted decrease in anti-inflammatory molecules and sphingolipids. Integrated analysis identified distinct molecular patterns distinguishing MS from controls. Additionally, multi-omics differences among different MS subtypes were uncovered. Notably, hippuric acid levels was consistently lower in MS subgroups with greater disease severity.Conclusion This study represents the pioneering exploration of multi-omics in Chinese MS patients, presenting a comprehensive view of the peripheral blood changes in MS. Our study underscores the robust capability of multi-omics assessments in identifying peripheral blood biomarkers that delineate the varied clinical presentation, and facilitates future development of biomarkers and targeted therapeutic interventions in MS.
WOS关键词B-CELL SUBSETS ; MEMORY ; MMP-2
资助项目Natural Science Foundation of China for Innovation Research Group[81821005] ; Shanghai Municipal Science and Technology Major Project ; Lingang Laboratory[LG202101-01-01] ; Medical-engineering cross fund of Shanghai Jiaotong University[YG2022QN009] ; Shandong Laboratory Program[SYS202205] ; National Natural Science Foundation of China[82201558]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001308130400001
出版者FRONTIERS MEDIA SA
源URL[http://119.78.100.183/handle/2S10ELR8/313314]  
专题新药研究国家重点实验室
通讯作者Hao, Yong; Geng, Meiyu; Zhang, Xiang; Chen, Sheng
作者单位1.Natl Ctr Neurol Disorders, Shanghai, Peoples R China
2.Fudan Univ, Inst Neurol, Shanghai, Peoples R China
3.Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Neurol, Shanghai, Peoples R China
6.Shanghai Green Valley Pharmaceut Co Ltd, Shanghai, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
8.Shanghai Jiao Tong Univ, Ruijin Hosp, Clin Ctr Rare Dis, Sch Med, Shanghai, Peoples R China
9.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China
10.Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Sch Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Qinming,Xie, Zuoquan,He, Lu,et al. Multi-omics profiling reveals peripheral blood biomarkers of multiple sclerosis: implications for diagnosis and stratification[J]. FRONTIERS IN PHARMACOLOGY,2024,15:12.
APA Zhou, Qinming.,Xie, Zuoquan.,He, Lu.,Sun, Guangqiang.,Meng, Huanyu.,...&Chen, Sheng.(2024).Multi-omics profiling reveals peripheral blood biomarkers of multiple sclerosis: implications for diagnosis and stratification.FRONTIERS IN PHARMACOLOGY,15,12.
MLA Zhou, Qinming,et al."Multi-omics profiling reveals peripheral blood biomarkers of multiple sclerosis: implications for diagnosis and stratification".FRONTIERS IN PHARMACOLOGY 15(2024):12.

入库方式： OAI收割

来源：上海药物研究所

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