Mitochondria-targeting near-infrared (NIR) materials orchestrating the symphony of precision diagnosis and therapy
文献类型：期刊论文
| 作者 | Gao, Shu1,3; Qu, Chunrong3; Wang, Jun1,3; Qian, Kun3; Cheng, Zhen1,2,3 |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 59页码:38 |
| 关键词 | Mitochondria targeting Near infrared Disease treatment Diagnosis |
| ISSN号 | 1748-0132 |
| DOI | 10.1016/j.nantod.2024.102478 |
| 通讯作者 | Qian, Kun(qiankun1@simm.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Mitochondria are essential for maintaining cellular survival and function, and their dysfunction is implicated in cancer, cardiovascular abnormalities, neurodegenerative diseases, aging, and so on, carrying significant pathophysiological implications. Conducting research focused on mitochondria helps elucidate the mechanisms of disease development and offers new therapeutic perspectives for combating challenging conditions like malignant tumors, myocardial injury, Parkinson's disease, and other related ailment. In recent years, the flourishing development of near-infrared (NIR) technology has provided powerful tools for mitochondrial research. NIR light serves as both an information carrier for biological imaging and analysis, and as a non-invasive stimulus in drug delivery, phototherapy, and energy conversion applications. Currently, a large number of NIR materials have been applied to target mitochondria in disease diagnosis, treatment, and theranostics. These materials have garnered significant attention due to their unique properties and remarkable in vivo performance. This review aims to provide researchers developing mitochondria-targeted NIR materials for biomedical applications with an advanced and comprehensive guide. It not only offers valuable insights into design strategies, material properties, and applications in disease diagnosis and treatment, such as strategies to improve imaging sensitivity, |
| WOS关键词 | PHOTODYNAMIC THERAPY ; REDOX HOMEOSTASIS ; COMPLEX-I ; CANCER ; HYPOXIA ; DISEASE ; DNA ; MEMBRANE ; DYSFUNCTION ; MECHANISM |
| 资助项目 | National Natural Science Foundation of China[U2267221] ; National Natural Science Foundation of China[81901799] ; Shanghai Municipal Science and Technology Major Project[TM202301H003] ; Gansu Science and Tech-nology Major Project[23ZDFA014] ; State Key Laboratory of Drug Research[SIMM0120231004] ; Shandong Laboratory Pro-gram[SYS202205] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001312323800001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313317]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Qian, Kun; Cheng, Zhen |
| 作者单位 | 1.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Shu,Qu, Chunrong,Wang, Jun,et al. Mitochondria-targeting near-infrared (NIR) materials orchestrating the symphony of precision diagnosis and therapy[J]. NANO TODAY,2024,59:38. |
| APA | Gao, Shu,Qu, Chunrong,Wang, Jun,Qian, Kun,&Cheng, Zhen.(2024).Mitochondria-targeting near-infrared (NIR) materials orchestrating the symphony of precision diagnosis and therapy.NANO TODAY,59,38. |
| MLA | Gao, Shu,et al."Mitochondria-targeting near-infrared (NIR) materials orchestrating the symphony of precision diagnosis and therapy".NANO TODAY 59(2024):38. |
入库方式： OAI收割
来源：上海药物研究所
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