Zexie-Baizhu Decoction ameliorates non-alcoholic fatty liver disease through gut-adipose tissue crosstalk
文献类型：期刊论文
| 作者 | Shi, Jingying4,5; Liu, Yawen4,5; Zhang, Zijia4,5; Zhong, Xianchun4,5; Cao, Yuhan4,5; Ni, Hui3; He, Qingqing5; Wang, Zhaojun4,5; Liu, Yameng4,5; Chen, Qinhua2 |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2025-01-30 |
| 卷号 | 337页码:14 |
| 关键词 | Zexie-Baizhu Decoction Traditional Chinese medicine Akkermansia muciniphila Bile acids Short chain fatty acid Lipidomics |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2024.118700 |
| 通讯作者 | Xie, Cen(xiecen@simm.ac.cn) ; Hou, Jinjun(jinjun_hou@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn) |
| 英文摘要 | Ethnopharmacological relevance: Zexie-Baizhu Decoction (AA), a Chinese Classical Formula composed of Alisma orientalis (Sam.) Juzep. and Aractylodes Macrocephala Koidz in the specific ratio of 5:2, has a long history of use in treating metabolic disorders. Recent studies have demonstrated AA's ameliorative effects on non-alcoholic fatty liver disease (NAFLD); however, the mechanism underlying its action on the gut and adipose tissue, key regulators of metabolism, have not been fully explored. Aim of the study: This study aimed to investigate the mechanisms by which AA regulates the homeostasis of gut and adipose tissue in NAFLD. Materials and methods: AA (1500 mg/kg/day) or vehicle was administrated to the high-fat diet-induced and normal chow-fed mice (C57BL/6J). Plasma, the liver, gut microbiota, bile acids, and short-chain fatty acids in the gut, were systematically investigated. RNA sequencing analysis, reverse transcription quantitative real-time PCR, and Western Blotting were performed on the epididymal white adipose tissues (eWAT) to explore AA's influence on NAFLD. Lipidomics of the liver and eWAT were analyzed by liquid chromatography-mass spectrometry and desorption electrospray ionization mass spectrometry imaging. Results: Our study demonstrated that AA administration effectively alleviated liver injury induced by NAFLD, as evidenced by reduced hepatic fat accumulation and inflammation. Mechanistically, AA modulated the composition of the gut microbiota, promoting the growth of beneficial bacteria such as Akkermansia muciniphila and restoring the balance between Firmicutes and Bacteroidetes. Furthermore, AA regulated the levels of bile acids and short-chain fatty acids in the intestine, plasma, and liver. Correspondingly in the eWAT, AA administration activated bile acid receptor (Gpbar1) and short-chain fatty acid receptor (Ffar2), facilitating lipid breakdown and attenuating triglyceride accumulation. Transcriptome analysis revealed that AA influenced gene expression related to fatty acid metabolism, thermogenesis, insulin resistance, AMPK signaling, and the tricarboxylic acid (TCA) cycle, thereby improving NAFLD at the transcriptional level. Additionally, AA treatment significantly altered the lipid composition in the liver, reducing levels of diacylglycerols, triacylglycerols, phosphatidylserines, and cholesterol esters, while increasing levels of phosphatidic acids, phosphatidylethanolamines, and sphingomyelins. |
| WOS关键词 | HEPATIC STEATOSIS ; MICROBIOTA ; OBESITY ; STEATOHEPATITIS ; METABOLISM |
| 资助项目 | National Natural Science Foundation of China[82374029] ; National Natural Science Foundation of China[81973470] ; Independent Project of the National Engineering Research Center of TCM Standardization Technology[2023-ZYBZH-04] ; Sanming Project of Medicine in Shenzhen[ZZYSM202106004] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:001309946000001 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313326]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xie, Cen; Hou, Jinjun; Wu, Wanying |
| 作者单位 | 1.BeiGene Shanghai Co Ltd, Shanghai, Peoples R China 2.Shenzhen Baoan Authent TCM Therapy Hosp, Anorectal Dept, Shenzhen 518101, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Inst Mat Med, Chinese Acad Sci, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Jingying,Liu, Yawen,Zhang, Zijia,et al. Zexie-Baizhu Decoction ameliorates non-alcoholic fatty liver disease through gut-adipose tissue crosstalk[J]. JOURNAL OF ETHNOPHARMACOLOGY,2025,337:14. |
| APA | Shi, Jingying.,Liu, Yawen.,Zhang, Zijia.,Zhong, Xianchun.,Cao, Yuhan.,...&Wu, Wanying.(2025).Zexie-Baizhu Decoction ameliorates non-alcoholic fatty liver disease through gut-adipose tissue crosstalk.JOURNAL OF ETHNOPHARMACOLOGY,337,14. |
| MLA | Shi, Jingying,et al."Zexie-Baizhu Decoction ameliorates non-alcoholic fatty liver disease through gut-adipose tissue crosstalk".JOURNAL OF ETHNOPHARMACOLOGY 337(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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