中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Major specialized natural products from the endangered plant Heptacodium miconioides, , potential medicinal uses and insights into its longstanding unresolved systematic classification

文献类型：期刊论文

作者Zhao, Ze-Yu4,5; Wan, Jiang5; Chen, Hao-Wei4,5; Sun, Zhong-Shuai5; Tao, Yu-Tian5; Tong, Yingpeng5; Zang, Yi3; Choo, Yeun-Mun2; Wang, Pan1; Li, Yue-Ling5
刊名PHYTOCHEMISTRY
出版日期2024-12-01
卷号228页码:15
关键词Heptacodium miconioides Caprifoliaceae Systematic position Chemotaxonomy Enantiomeric lignans Triterpenoids Quinic acid derivatives ACL inhibitory
ISSN号0031-9422
DOI10.1016/j.phytochem.2024.114259
通讯作者Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要A comprehensive phytochemical investigation of the flower buds and leaves/twigs of Heptacodium miconioides, a cultivated ornamental plant native to China and categorized as 'vulnerable', has led to the isolation of 45 structurally diverse compounds, which comprise 18 phenylpropanoids (1-4, 7-20), 11 pentacyclic triterpenoids (5, 6, 21-29), eight secoiridoid glycosides (30-37), three quinic acid derivatives (38-40), and a few miscellaneous components (41-45). Among them, (+)-alpha-intermedianol (1), (+)-holophyllol A (2), and (-)-pseudolarkaemin A (3) represent previously unreported enantiomeric lignans, while (+)-7 '(R)-hydroxymatairesinol (4) is an undescribed naturally occurring lignan. Heptacoacids A (5) and B (6) are undescribed 24-nor-urs-28-oic acid derivatives. Their chemical structures were determined by 2D-NMR, supplemented by evidence from specific rotations and circular dichroism spectra. Given the uncertainty surrounding the systematic position of Heptacodium, integrative taxonomy (ITA), a method utilized to define contentious species, is applied. Chemotaxonomy, a vital aspect of ITA, becomes significant. By employing hierarchical clustering analysis (HCA) and syntenic pattern analysis methods, a taxonomic examination based on the major specialized natural products from the flower buds of H. miconioides and two other Caprifoliaceae plants (i.e., Lonicera japonica and Abelia x grandiflora) could offer enhanced understanding of the systematic placement of Heptacodium. Additionally, compounds 39 and 40 displayed remarkable inhibitory activities against ATP-citrate lyase (ACL), with IC50 values of 0.11 and 1.10 mu M, respectively. In summary, the discovery of medical properties and refining systematic classification can establish a sturdy groundwork for conservation efforts aimed at mitigating species diversity loss while addressing human diseases.
WOS关键词CHEMICAL-CONSTITUENTS ; IRIDOID GLUCOSIDES ; BEMPEDOIC ACID ; URSOLIC ACID ; LIGNANS ; CAPRIFOLIACEAE ; INHIBITORS ; DIPSACALES ; TRITERPENE ; PHYLOGENY
资助项目National Natural Science Foundation of China[21937002] ; National Natural Science Foundation of China[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001] ; Zhejiang Provincial Natural Science Foundation of China[LTY22C030002]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001312538800001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/313329]  
专题新药研究国家重点实验室
通讯作者Hu, Jin-Feng
作者单位1.Tradit Chinese Med Ind Dev & Promot Ctr Panan Cty, Panan 322300, Zhejiang, Peoples R China
2.Univ Malaya, Fac Sci, Chem Dept, Kuala Lumpur 50603, Malaysia
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
5.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Taizhou 318000, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Ze-Yu,Wan, Jiang,Chen, Hao-Wei,et al. Major specialized natural products from the endangered plant Heptacodium miconioides, , potential medicinal uses and insights into its longstanding unresolved systematic classification[J]. PHYTOCHEMISTRY,2024,228:15.
APA Zhao, Ze-Yu.,Wan, Jiang.,Chen, Hao-Wei.,Sun, Zhong-Shuai.,Tao, Yu-Tian.,...&Hu, Jin-Feng.(2024).Major specialized natural products from the endangered plant Heptacodium miconioides, , potential medicinal uses and insights into its longstanding unresolved systematic classification.PHYTOCHEMISTRY,228,15.
MLA Zhao, Ze-Yu,et al."Major specialized natural products from the endangered plant Heptacodium miconioides, , potential medicinal uses and insights into its longstanding unresolved systematic classification".PHYTOCHEMISTRY 228(2024):15.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。