Multivariate approach to assess the bioactive compounds of Atractylodes chinensis (DC.) Koidz in different harvest periods
文献类型：期刊论文
| 作者 | Liu, Xiaokang2,3; Liang, Liwen3; Cai, Guangzhi3; Guo, Yunlong1; Gong, Jiyu3 |
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2024-10-01 |
| 卷号 | 1246页码:12 |
| 关键词 | Atractylodes chinensis (DC.) Koidz Bioactive compound Harvest period Atractylodes chinensis (DC.) Koidz Metabolomics Bioactive compound Harvest period |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2024.124298 |
| 通讯作者 | Guo, Yunlong(Guoyl02@ccucm.edu.cn) |
| 英文摘要 | Background: The Atractylodes chinensis (DC.) Koidz (A. chinensis) Chinese herb possesses numerous therapeutic properties and is extensively utilized in the pharmaceutical industry. Its quality is closely associated with the harvest periods. However, the optimal quality and harvest periods of A. chinensis remain elusive. Methods: The bioactive compounds of perennial A. chinensis were detected by ultra-high-performance liquid chromatography coupled with quadrupole Orbitrap mass spectrometry (UHPLC-Q-Orbitrap/MS) metabolomics, and differentially abundant compounds were selected by multivariate statistical analysis. Then, variations in the content of differential compounds in samples harvested at different periods were analyzed, while correlation analysis was carried out on the differential compounds to determine the suitable harvest period for distinct components. Results: A total of 61 bioactive compounds were detected in all samples, grouped into 9 known classes. The results revealed that the chemical compositions of A. chinensis at different harvest periods were significantly different. The volatile oil content in the four-year-old and five-year-old samples was relatively high, at 31.92 mg/g and 32.42 mg/g, respectively. There were also significant differences in the content of the six active ingredients, for example, the five-year-old sample had the highest content of atractylodin (4.38 mg/g). Indeed, the harvest period was correlated with the abundance of most bioactive compounds. Specifically, quinquennial samples were significantly negatively correlated with the abundance of organic acids and aliphatics while moderately positively correlated with the abundance of other classes of bioactive compounds. Conclusions: According to the results, the ideal harvest time for atractylenolide III was 3 years. Regarding organic acids, the optimal harvest time was around 2-3 years. Taken together, these results offer valuable insights to producers for optimizing the harvest period for A. chinensis. |
| 资助项目 | Jilin Natural Science Foundation, China[20210204078YY] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001312329300001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313353]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Yunlong |
| 作者单位 | 1.Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun 130117, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiaokang,Liang, Liwen,Cai, Guangzhi,et al. Multivariate approach to assess the bioactive compounds of Atractylodes chinensis (DC.) Koidz in different harvest periods[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2024,1246:12. |
| APA | Liu, Xiaokang,Liang, Liwen,Cai, Guangzhi,Guo, Yunlong,&Gong, Jiyu.(2024).Multivariate approach to assess the bioactive compounds of Atractylodes chinensis (DC.) Koidz in different harvest periods.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1246,12. |
| MLA | Liu, Xiaokang,et al."Multivariate approach to assess the bioactive compounds of Atractylodes chinensis (DC.) Koidz in different harvest periods".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1246(2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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