Self-Assembling Ceramide 2-Cyclodextrin Inclusion Nanoparticles for Corneal Repair
文献类型：期刊论文
| 作者 | Yan, Y. T.4,5; Liu, L.2,3; Lin, X. F.4,5; Wei, Y. X.2; Ren, H. H.4,5; Wang, W.1; He, X. J.4,5; Li, X. M.4,5; Liu, E. G.2 |
| 刊名 | COLLOID JOURNAL
 |
| 出版日期 | 2024-08-01 |
| 卷号 | 86期号:4页码:644-654 |
| 关键词 | ceramide-2 corneal repair inclusion complex self-assembly nanoparticles |
| ISSN号 | 1061-933X |
| DOI | 10.1134/S1061933X24600313 |
| 通讯作者 | Li, X. M.(lixiaomin@perfect99.com) ; Liu, E. G.(liuergang@zidd.ac.cn) |
| 英文摘要 | Ceramide 2 is the main lipid of stratum corneum and a popular component in skin healthcare products. But developing ceramide 2 based corneal protecting product is troublesome due to its insoluble feature in water. In this work, a novel type of inclusion nanoparticle was developed to solubilize and enhance the corneal repair effect of ceramide 2 by the anti-solvent method. It was revealed that the types of solvents and cyclodextrins influenced the precipitation rate as well as the stability of intermediate clusters of ceramide 2, where DMSO with moderate supersaturation promoted the formation of inclusion complex with beta-cyclodextrins. The ceramide-cyclodextrin inclusion complex had an amphiphilic structure, which could self-assemble into nanoparticles in water, as evidenced by disappeared endothermic peaks of ceramide (78 degrees C) and cyclodextrin (120 degrees C), as well as appearance of two endothermic peaks corresponding to nanoparticle transition (45 degrees C) and dissociation of cyclodextrin inclusion complex (102 degrees C). Upon treating rat damaged skins with ceramide 2 inclusion nanoparticles, the cumulative permeation of indomethacin (IND, a model drug for skin permeability) were found to be 330.80 +/- 54.86 mu g/cm(2), which was significantly lower than the control group (472.47 +/- 154.83 mu g/cm(2)). In comparison, water suspensions of ceramide 2 showed no corneal repair effect. |
| WOS关键词 | SKIN ; CYCLODEXTRIN ; ENHANCEMENT ; COMPLEX ; ACID |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001307884600008 |
| 出版者 | PLEIADES PUBLISHING INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313362]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, X. M.; Liu, E. G. |
| 作者单位 | 1.Zunyi Med Univ, Sch Pharm, Zunyi 563003, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China 3.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China 4.Perfect Life Sci Res Inst Co Ltd, Zhongshan 528400, Peoples R China 5.Perfect Guangdong Commod Co LTD, Zhongshan 528451, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Y. T.,Liu, L.,Lin, X. F.,et al. Self-Assembling Ceramide 2-Cyclodextrin Inclusion Nanoparticles for Corneal Repair[J]. COLLOID JOURNAL,2024,86(4):644-654. |
| APA | Yan, Y. T..,Liu, L..,Lin, X. F..,Wei, Y. X..,Ren, H. H..,...&Liu, E. G..(2024).Self-Assembling Ceramide 2-Cyclodextrin Inclusion Nanoparticles for Corneal Repair.COLLOID JOURNAL,86(4),644-654. |
| MLA | Yan, Y. T.,et al."Self-Assembling Ceramide 2-Cyclodextrin Inclusion Nanoparticles for Corneal Repair".COLLOID JOURNAL 86.4(2024):644-654. |
入库方式： OAI收割
来源：上海药物研究所
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