Ligand-Controlled Enantioselective and Regiodivergent Construction of 1,2-and 1,3-Disubstituted Alicycles
文献类型：期刊论文
| 作者 | Zeng, Ke2,3; Li, Ludi1; Luo, Xiaoyao2; Wang, Yue3; Song, Xiaorong3; Zhang, Pengli3; Xia, Guoqin3 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2024-09-10 |
| 卷号 | 26期号:37页码:7938-7943 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.4c02975 |
| 通讯作者 | Zhang, Pengli(zhangpengli@zidd.ac.cn) ; Xia, Guoqin(xiaguoqin@simm.ac.cn) |
| 英文摘要 | Three-dimensional alicyclic skeletons with multiple stereochemically defined chiral centers are highly valuable in modern drug discovery. Here, we reported a diverse approach to access 1,2- and 1,3-disubstituted chiral cycloalkanes by the strategy of NiH-catalyzed, transannular-directed alkene desymmetrization. The ring strain of the bridged bicyclic organonickel intermediate and the coordination effect of the ligand were identified as crucial factors in determining site selectivity by influencing the NiH migration step. This methodology demonstrates a broad substrate scope and displays good tolerance toward various functional groups, resulting in excellent outcomes in terms of the yield, regioselectivity, and enantioselectivity. |
| WOS关键词 | DESIGN |
| 资助项目 | Chinese Academy of Sciences ; National Natural Science Foundation of China[22271297] ; Program for Talented Young Investigators of Guangdong Province[2021QN020533] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001310124200001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313365]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Pengli; Xia, Guoqin |
| 作者单位 | 1.Guizhou Med Univ, Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, Sch Pharm, Guiyang 550025, Guizhou, Peoples R China 2.Zunyi Med Univ, Sch Pharm, Zunyi 563006, Guizhou, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Ke,Li, Ludi,Luo, Xiaoyao,et al. Ligand-Controlled Enantioselective and Regiodivergent Construction of 1,2-and 1,3-Disubstituted Alicycles[J]. ORGANIC LETTERS,2024,26(37):7938-7943. |
| APA | Zeng, Ke.,Li, Ludi.,Luo, Xiaoyao.,Wang, Yue.,Song, Xiaorong.,...&Xia, Guoqin.(2024).Ligand-Controlled Enantioselective and Regiodivergent Construction of 1,2-and 1,3-Disubstituted Alicycles.ORGANIC LETTERS,26(37),7938-7943. |
| MLA | Zeng, Ke,et al."Ligand-Controlled Enantioselective and Regiodivergent Construction of 1,2-and 1,3-Disubstituted Alicycles".ORGANIC LETTERS 26.37(2024):7938-7943. |
入库方式： OAI收割
来源：上海药物研究所
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