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Reactive Oxygen Species Triggered Cleavage of Thioketal-Containing Supramolecular Nanoparticles for Inflammation-Targeted Oral Therapy in Ulcerative Colitis

文献类型：期刊论文

作者Xiong, Ting3,4; Xu, Huipeng2,3; Nie, Qin3,4; Jia, Bingqian2,3; Bao, Haojie3,4; Zhang, Hanwen3,4; Li, Jing2,3; Cao, Zeying2,3; Wang, Shunyao1; Wu, Li3,4
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2024-09-19
页码13
关键词anti-inflammation inflammation-targeted ROS-responsive thioketal supramolecular nanoparticles ulcerative colitis
ISSN号1616-301X
DOI10.1002/adfm.202411979
通讯作者Wu, Li(wuli@simm.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要Combating reactive oxygen species (ROS) and targeted drug delivery to inflammatory sites are considered effective therapeutic strategies for ulcerative colitis (UC), a refractory chronic inflammatory disease. Herein, a ROS-responsive thioketal (TK) crosslinked cyclodextrin metal-organic framework (TCOF) is fabricated, to which a non-ROS-sensitive vector, sulfur substituted by carbon chain-crosslinked cyclodextrin metal-organic framework (CCOF) is parallelly designed as ROS negative reference. Dexamethasone (DEX) loaded in TCOF (TCD) and CCOF (CCD) are investigated to demonstrate the advantages of precision medicine for UC. After the ROS-induced collapse of nanoparticles, TCD selectively triggered the release of DEX. Moreover, TCD effectively protected cells from oxidative stress damage and reduced inflammation levels in vitro. Remarkably, the TK group of TCD is oxidatively broken by consuming ROS at the inflammatory site, exposing the thiol group to mucosal adhesion, which enhances the retention of TCD at colons. In vivo studies of UC treatment reveals that oral administration of TCD demonstrated excellent inflammation-targeting properties, remarkably attenuated oxidative stress, and ameliorated both acute and chronic colitis compared to CCD. Furthermore, TCD exhibits an excellent safety profile in mice. These results instill confidence in advancing targeted drug delivery and precision therapy for UC. This study designed a novel reactive oxygen species-responsive thioketal cyclodextrin metal-organic framework (TCOF) and dexamethasone-loaded TCOF nanoparticles (TCD) are employed for inflammation-targeted oral therapy in ulcerative colitis. TCD nanoparticles specifically delivers dexamethasone to the inflamed colon and effectively alleviated the symptoms of both acute and chronic colitis. image
WOS关键词METAL-ORGANIC FRAMEWORKS ; BOWEL-DISEASE ; CD-MOF ; DELIVERY ; ENCAPSULATION ; CURCUMIN
资助项目National Natural Science Foundation of China ; Shanghai Advanced Research Institute, Chinese Academy of Sciences ; [82273863]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:001315054600001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/313436]  
专题中国科学院上海药物研究所
通讯作者Wu, Li; Zhang, Jiwen
作者单位1.Beijing Sunny Med Technol Co Ltd, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China
4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714		 Xiong, Ting,Xu, Huipeng,Nie, Qin,et al. Reactive Oxygen Species Triggered Cleavage of Thioketal-Containing Supramolecular Nanoparticles for Inflammation-Targeted Oral Therapy in Ulcerative Colitis[J]. ADVANCED FUNCTIONAL MATERIALS,2024:13.
APA Xiong, Ting.,Xu, Huipeng.,Nie, Qin.,Jia, Bingqian.,Bao, Haojie.,...&Zhang, Jiwen.(2024).Reactive Oxygen Species Triggered Cleavage of Thioketal-Containing Supramolecular Nanoparticles for Inflammation-Targeted Oral Therapy in Ulcerative Colitis.ADVANCED FUNCTIONAL MATERIALS,13.
MLA Xiong, Ting,et al."Reactive Oxygen Species Triggered Cleavage of Thioketal-Containing Supramolecular Nanoparticles for Inflammation-Targeted Oral Therapy in Ulcerative Colitis".ADVANCED FUNCTIONAL MATERIALS (2024):13.

入库方式： OAI收割

来源：上海药物研究所

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