中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Concise chemoenzymatic synthesis of N-glycans

文献类型：期刊论文

作者Wei, Fangyu3,4,5; Zang, Lanlan2; Zhang, Pengfei4,5; Zhang, Jiabin1,3,5; Wen, Liuqing3,4,5
刊名CHEM
出版日期2024-09-12
卷号10期号:9页码:18
ISSN号2451-9294
DOI10.1016/j.chempr.2024.05.006
通讯作者Wen, Liuqing(lwen@simm.ac.cn)
英文摘要Structure-defined N-glycans are essential tools to uncover the molecular basis of N-glycan functions. However, the difficulty in obtaining diverse collections of well-defined N-glycans has always been an obstacle that greatly hampers progress in glycoscience. Here, we developed a general platform for the concise total synthesis of N-glycans. Using the designed strategy, the general N-gly can precursors, including core pentasaccharide and core tetrasaccharide, were successfully assembled from common starting materials in only a few facile chemical and enzymatic steps. Starting from core pentasaccharide and core tetrasaccharide, a variety of biantennary N-glycans were prepared successfully in large quantities by taking advantage of enzymatic diversification. In particular, reverse galactosylation was employed as a selective protecting strategy, by which complex asymmetric N-glycans could be obtained easily and efficiently.
WOS关键词FACILE ENZYMATIC-SYNTHESIS ; PROTEIN GLYCOSYLATION ; BINDING ; ALG2 ; SIALYLTRANSFERASE ; IDENTIFICATION ; GLYCOPEPTIDES ; PATHWAY ; FUT8 ; TRI
资助项目Talent Plan of Shanghai Branch, Chinese Academy of Sciences[CASSHB-QNPD-2023-018] ; Natural Science Foundation of Shanghai[22ZR1474000] ; Shanghai Municipal Science and Technology Major Project ; Natural Science Foundation of Shandong Province[ZR2021QH231]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001316323800001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/313442]  
专题中国科学院上海药物研究所
通讯作者Wen, Liuqing
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China
2.Linyi Peoples Hosp, Cent Lab, Linyi 276000, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
5.Carbohydrate Based Drug Res Ctr, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Fangyu,Zang, Lanlan,Zhang, Pengfei,et al. Concise chemoenzymatic synthesis of N-glycans[J]. CHEM,2024,10(9):18.
APA Wei, Fangyu,Zang, Lanlan,Zhang, Pengfei,Zhang, Jiabin,&Wen, Liuqing.(2024).Concise chemoenzymatic synthesis of N-glycans.CHEM,10(9),18.
MLA Wei, Fangyu,et al."Concise chemoenzymatic synthesis of N-glycans".CHEM 10.9(2024):18.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。