Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression
文献类型：期刊论文
| 作者 | Lai, Mengyu4; Li, Jiaomeng3; Yang, Jiaying4; Zhang, Qingli3 ; Gong, Yujia4; Ma, Yuhang4; Fang, Fang4; Li, Na4; Zhai, Yingxiang2,3; Shen, Tingting4
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| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
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| 出版日期 | 2024-09-23 |
| 卷号 | 16期号:3页码:11 |
| 关键词 | gestational diabetes mellitus metabolomics cysteine |
| ISSN号 | 1674-2788 |
| DOI | 10.1093/jmcb/mjae010 |
| 通讯作者 | Liu, Jia(jia.liu@simm.ac.cn) ; Wang, Yufan(yyffwang@sina.com) |
| 英文摘要 | Gestational diabetes mellitus (GDM) is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes, but its pathogenesis has not been clearly elucidated. Investigations of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM progression. Therefore, in the present study, we analysed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance throughout the three trimesters. We found that the variation trends of 38 metabolites were significantly changed during GDM development. Specifically, longitudinal analyses revealed that cysteine (Cys) levels significantly decreased over the course of GDM progression. Further study showed that Cys alleviated GDM in female mice at gestational day 14.5, possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic gluconeogenesis. Taken together, these findings suggest that the Cys metabolism pathway might play a crucial role in GDM and Cys supplementation represents a potential new treatment strategy for GDM patients. |
| WOS关键词 | OXIDATIVE STRESS ; GLUCOSE ; SUPPLEMENTATION ; HYPERGLYCEMIA ; INFLAMMATION ; PREGNANCY ; ACID |
| 资助项目 | National Natural Science Foundation of China[81870610] ; Shanghai Science and Technology Commission Foundation[21Y11904800] ; Shanghai Science and Technology Commission Foundation[23ZR1451500] ; Clinical Research Plan of SHDC[SHDC2020CR3065B] ; National Key Research and Development Program of China[2021YFC2501600] ; National Key Research and Development Program of China[2021YFC2501601] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001317810200001 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313445]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Jia; Wang, Yufan |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310058, Peoples R China 2.Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Endocrinol & Metab, Shanghai 200080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, Mengyu,Li, Jiaomeng,Yang, Jiaying,et al. Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2024,16(3):11. |
| APA | Lai, Mengyu.,Li, Jiaomeng.,Yang, Jiaying.,Zhang, Qingli.,Gong, Yujia.,...&Wang, Yufan.(2024).Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression.JOURNAL OF MOLECULAR CELL BIOLOGY,16(3),11. |
| MLA | Lai, Mengyu,et al."Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression".JOURNAL OF MOLECULAR CELL BIOLOGY 16.3(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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