The stability of FKBP9 maintained by BiP is crucial for glioma progression
文献类型：期刊论文
| 作者 | Li, Shirong6,7,8,9; Xia, Wangxiao5; Sun, Bin6,7,8,9; Peng, Weiyan4; Yang, Dong6,7,8,9; Gao, Jing2,3; He, Shuai6,7,8,9; Yang, Hua1,5; Zhu, Yongjie6,7,8,9; Zhou, Hu2,3
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| 刊名 | GENES & DISEASES
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| 出版日期 | 2024-11-01 |
| 卷号 | 11期号:6页码:11 |
| 关键词 | BiP Endoplasmic reticulum stress FKBP9 Glioma Knockout mice |
| ISSN号 | 2352-4820 |
| DOI | 10.1016/j.gendis.2023.101123 |
| 通讯作者 | Xiang, Tingxiu(xiangtx@cqmu.edu.cn) ; Kong, Qingpeng(kongqp@mail.kiz.ac.cn) ; Zhao, Xudong(zhaoxudong@wchscu.cn) |
| 英文摘要 | FK506-binding protein 9 (FKBP9) is involved in tumor malignancy by resistance to endoplasmic reticulum (ER) stress, and the up-regulation of FKBP9 is associated with patients' poor prognosis. The current knowledge of the molecular mechanisms is still limited. One previous study showed that FKBP9 could confer glioblastoma cell resistance to ER stress through ASK1-p38 signaling. However, the upstream regulatory mechanism of FKBP9 expression is still indistinct. In this study, we identified the FKBP9 binding proteins using co-immunoprecipitation followed by mass spectrometry. Results showed that FKBP9 interacted with the binding immunoglobulin protein (BiP). BiP bound directly to FKBP9 with high affinity. BiP prolonged the halflife of the FKBP9 protein and stabilized the FKBP9 protein. BiP and FKBP9 protein levels were positively correlated in patients with glioma, and patients with high expression of BiP and FKBP9 showed a worse prognosis. Further studies showed that FKBP9 knockout in genetically engineered mice inhibited intracranial glioblastoma formation and prolonged survival by decreasing cellular proliferation and ER stress-induced CHOP-related apoptosis. Moreover, normal cells may depend less on FKBP9, as shown by the absence of apoptosis upon FKBP9 knockdown in a non-transformed human cell line and overall normal development in homozygous knockout mice. These findings suggest an important role of BiP-regulated FKBP9-associated signaling in glioma progression and the BiP-FKBP9 axis may be a potential therapeutic target for glioma. (c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/). |
| WOS关键词 | ER CHAPERONE ; GRP78 ; BINDING ; TARGET ; STABILIZATION ; PROTEINS ; STRESS |
| 资助项目 | National Natural Science Foundation of China[82103107] ; State Key Laboratory of Genetic Resources and Evolution of China[GREKF19-06] ; The 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University[ZYYC20002] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:001318240200001 |
| 出版者 | KEAI PUBLISHING LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313448]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xiang, Tingxiu; Kong, Qingpeng; Zhao, Xudong |
| 作者单位 | 1.Third Peoples Hosp Yunnan Prov, Kunming 650600, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, Shanghai 201203, Peoples R China 4.Chongqing Med Univ, Affiliated Hosp 1, Key Lab Mol Oncol & Epigenet, Chongqing 400016, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Key Lab Hlth Aging Res Yunnan Prov, Kunming 650223, Yunnan, Peoples R China 6.Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Chengdu 610041, Sichuan, Peoples R China 7.Sichuan Univ, West China Hosp, State Key Lab Resp Hlth & Multimorbid, Chengdu 610041, Sichuan, Peoples R China 8.Sichuan Univ, West China Hosp, Canc Ctr, Lab Anim Tumor Models, Chengdu 610041, Sichuan, Peoples R China 9.Sichuan Univ, West China Hosp, Div Abdominal Tumor Multimodal Treatment, Chengdu 610041, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shirong,Xia, Wangxiao,Sun, Bin,et al. The stability of FKBP9 maintained by BiP is crucial for glioma progression[J]. GENES & DISEASES,2024,11(6):11. |
| APA | Li, Shirong.,Xia, Wangxiao.,Sun, Bin.,Peng, Weiyan.,Yang, Dong.,...&Zhao, Xudong.(2024).The stability of FKBP9 maintained by BiP is crucial for glioma progression.GENES & DISEASES,11(6),11. |
| MLA | Li, Shirong,et al."The stability of FKBP9 maintained by BiP is crucial for glioma progression".GENES & DISEASES 11.6(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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