Global marine microbial diversity and its potential in bioprospecting
文献类型：期刊论文
| 作者 | Chen, Jianwei17,18,19,20; Jia, Yangyang19; Sun, Ying18,20; Liu, Kun16; Zhou, Changhao20; Liu, Chuan17,19; Li, Denghui20; Liu, Guilin20; Zhang, Chengsong16; Yang, Tao14,15 |
| 刊名 | NATURE
 |
| 出版日期 | 2024-09-04 |
| 页码 | 27 |
| ISSN号 | 0028-0836 |
| DOI | 10.1038/s41586-024-07891-2 |
| 英文摘要 | The past two decades has witnessed a remarkable increase in the number of microbial genomes retrieved from marine systems1,2. However, it has remained challenging to translate this marine genomic diversity into biotechnological and biomedical applications3,4. Here we recovered 43,191 bacterial and archaeal genomes from publicly available marine metagenomes, encompassing a wide range of diversity with 138 distinct phyla, redefining the upper limit of marine bacterial genome size and revealing complex trade-offs between the occurrence of CRISPR-Cas systems and antibiotic resistance genes. In silico bioprospecting of these marine genomes led to the discovery of a novel CRISPR-Cas9 system, ten antimicrobial peptides, and three enzymes that degrade polyethylene terephthalate. In vitro experiments confirmed their effectiveness and efficacy. This work provides evidence that global-scale sequencing initiatives advance our understanding of how microbial diversity has evolved in the oceans and is maintained, and demonstrates how such initiatives can be sustainably exploited to advance biotechnology and biomedicine. Analysis of 43,191 genomes obtained from publicly available marine bacterial and archaeal metagenome data provides insights into marine bacterial evolution, CRISPR-Cas defence and antibiotic resistance genes, and demonstrates the potential of marine metagenomes for biotechnological applications. |
| WOS关键词 | CRISPR-CAS ; ASSEMBLED GENOMES ; BACTERIAL ; IDENTIFICATION ; COMMUNITY ; BIODEGRADATION ; ANNOTATION ; EVOLUTION ; INSIGHT ; GENES |
| 资助项目 | National Key Research and Development Program of China[2019YFA0706900] ; Key Program of Marine Economy Development (Six Marine Industries) Special Foundation of Department of Natural Resources of Guangdong Province[[2023]49] ; Joint Funds of the National Natural Science Foundation of China[U2106228] ; National Natural Science Foundation of China[32100047] ; National Natural Science Foundation of China[32025001] ; National Natural Science Foundation of China[32370124] ; Major Scientific and Technological Innovation Projects of Qingdao West Coast New Area[ZDKC-2022-03] ; Thousands Marine Species Genome Sequencing Project of Qingdao Free Trade Zone Management Committee[B23YQ2003] ; Project of Sanya Yazhou Bay Science and Technology City[SKJC-2024-02-003] ; State Key Laboratory of Microbial Technology Open Projects Fund (M2023-10) ; Global Ocean Microbiome Project (GOMP) |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001306513900013 |
| 出版者 | NATURE PORTFOLIO |
| 资助机构 | National Key Research and Development Program of China ; Key Program of Marine Economy Development (Six Marine Industries) Special Foundation of Department of Natural Resources of Guangdong Province ; Joint Funds of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major Scientific and Technological Innovation Projects of Qingdao West Coast New Area ; Thousands Marine Species Genome Sequencing Project of Qingdao Free Trade Zone Management Committee ; Project of Sanya Yazhou Bay Science and Technology City ; State Key Laboratory of Microbial Technology Open Projects Fund (M2023-10) ; Global Ocean Microbiome Project (GOMP) |
| 源URL | [http://ir.idsse.ac.cn/handle/183446/11426]  |
| 专题 | 深海科学研究部_深海生物学研究室_海洋哺乳动物与海洋生物声学研究组 |
| 通讯作者 | Sun, Ying; Mock, Thomas; Li, Shengying; Zhang, Wenwei; Fan, Guangyi |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 2.Univ East Anglia, Sch Environm Sci, Norwich Res Pk, Norwich, England 3.BGI Res, State Key Lab Agr Genom, Shenzhen, Peoples R China 4.Second Peoples Hosp Liaocheng, Dept Neurol, Liaocheng, Peoples R China 5.Liaocheng Peoples Hosp, Joint Lab Translat Med Res, Liaocheng, Peoples R China 6.BGI Res, Sanya, Peoples R China 7.Hong Kong Polytech Univ, PolyU BGI Joint Res Ctr Genom & Synthet Biol Globa, Hong Kong, Peoples R China 8.Hong Kong Polytech Univ, Dept Food Sci & Nutr, Hong Kong, Peoples R China 9.Nanjing Tech Univ, Coll Food Sci & Light Ind, Nanjing, Peoples R China 10.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Marine Mammal & Marine Bioacoust Lab, Sanya, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jianwei,Jia, Yangyang,Sun, Ying,et al. Global marine microbial diversity and its potential in bioprospecting[J]. NATURE,2024:27. |
| APA | Chen, Jianwei.,Jia, Yangyang.,Sun, Ying.,Liu, Kun.,Zhou, Changhao.,...&Fan, Guangyi.(2024).Global marine microbial diversity and its potential in bioprospecting.NATURE,27. |
| MLA | Chen, Jianwei,et al."Global marine microbial diversity and its potential in bioprospecting".NATURE (2024):27. |
入库方式： OAI收割
来源：深海科学与工程研究所
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