Srebp-1 bridges gonad development and lipid accumulation by regulating lipogenesis in noble scallop Chlamys nobilis
文献类型：期刊论文
| 作者 | Jiang, Danli3; Zhang, Hongkuan2; Liu, Runlin1,3; Zheng, Huaiping2; Liu, Helu1
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2024-11-01 |
| 卷号 | 279页码:10 |
| 关键词 | Chlamys nobilis Srebp-1 Gonad development Lipid accumulation Cold exposure |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2024.135094 |
| 英文摘要 | In bivalve, development of female gonad is accompanied with accumulating lipids which provided energy resource for non-feeding larvae development. As the major transcriptional regulators of lipid metabolism, Srebps play pivotal role in lipid homeostasis during oogenesis. However, little work was conducted on Srebps function in bivalves. The noble scallop Chlamys nobilis accumulated large amount of lipids in its gonad during oogenesis. Here, we identified a single Srebp gene (named Srebp-1) with a high similarity to human Srebp-1c. Disrupting Srebp-1 with Betulin (inhibiting the maturation of Srebp protein) repressed expression of lipogenic genes and de novo lipogenesis, and resulted in reduction of gonad index and lipid deposition, suggesting a crucial role of Srebp1 for gonad development and lipid synthesis in female gonad. Additionally, scallops with Srebp-1 disruption released fewer eggs with a reduction in their lipid content and D-larvae formation, revealing an impair of fecundity caused by Srebp-1 disruption. Cold exposure stimulated lipid accumulation which required Srebp-1 to regulate de novo lipogenesis and lipid uptake, providing a crosstalk of Srebp-1 activity and environmental variation on lipid accumulation in noble scallop. Thus, our study identified Srebp-1 as a central regulator coordinating the lipid synthesis and accumulation with gonad development in noble scallop. |
| WOS关键词 | ELEMENT-BINDING-PROTEIN ; CRASSOSTREA-GIGAS ; BIVALVE PECTINIDAE ; SMALL-MOLECULE ; TEMPERATURE ; QUALITY ; HISTOCHEMISTRY ; METABOLISM ; ACTIVATION ; EXPRESSION |
| 资助项目 | National Natural Science Foundation of China[41606152] ; National Natural Science Foundation of China[42206102] ; Hainan Provincial Natural Science Foundation of China[823QN247] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001312908300001 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; Hainan Provincial Natural Science Foundation of China |
| 源URL | [http://ir.idsse.ac.cn/handle/183446/11398]  |
| 专题 | 深海科学研究部_深海生物学研究室_海洋生物生态与进化研究组 |
| 通讯作者 | Liu, Helu |
| 作者单位 | 1.Chinese Acad Sci, Inst Deep Sea Sci & Engn, 28 Luhuitou Rd, Sanya 572000, Hainan, Peoples R China 2.Shantou Univ, Key Lab Marine Biotechnol Guangdong Prov, Shantou 515063, Peoples R China 3.Hainan Med Univ, Int Ctr Aging & Canc, Haikou 570102, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Danli,Zhang, Hongkuan,Liu, Runlin,et al. Srebp-1 bridges gonad development and lipid accumulation by regulating lipogenesis in noble scallop Chlamys nobilis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,279:10. |
| APA | Jiang, Danli,Zhang, Hongkuan,Liu, Runlin,Zheng, Huaiping,&Liu, Helu.(2024).Srebp-1 bridges gonad development and lipid accumulation by regulating lipogenesis in noble scallop Chlamys nobilis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,279,10. |
| MLA | Jiang, Danli,et al."Srebp-1 bridges gonad development and lipid accumulation by regulating lipogenesis in noble scallop Chlamys nobilis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 279(2024):10. |
入库方式： OAI收割
来源：深海科学与工程研究所
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