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Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption

文献类型：期刊论文

作者Zhang, Qingsong4; Fu, Jianxin4; Lin, Hong4; Xuan, Guanhua4; Zhang, Weiwei1; Chen, Lingxin2; Wang, Guoqing3,4
刊名BIOTECHNOLOGY JOURNAL
出版日期2024-05-01
卷号19期号:5页码:11
关键词antibacterial mechanism biofilm carbon dot one-step reaction photoactivation
ISSN号1860-6768
DOI10.1002/biot.202400156
通讯作者Xuan, Guanhua(xuanguanhua@ouc.edu.cn) ; Wang, Guoqing(gqwang@ouc.edu.cn)
英文摘要In spite of tremendous efforts dedicated to addressing bacterial infections and biofilm formation, the post-antibiotic ear continues to witness a gap between the established materials and an easily accessible yet biocompatible antibacterial reagent. Here we show carbon dots (CDs) synthesized via a single hydrothermal process can afford promising antibacterial activity that can be further enhanced by exposure to light. By using citric acid and polyethyleneimine as the precursors, the photoluminescence CDs can be produced within a one-pot, one-step hydrothermal reaction in only 2 h. The CDs demonstrate robust antibacterial properties against both Gram-positive and Gram-negative bacteria and, notably, a considerable enhancement of antibacterial effect can be observed upon photo-irradiation. Mechanistic insights reveal that the CDs generate singlet oxygen (1O2) when exposed to light, leading to an augmented reactive oxygen species level. The approach for disruption of biofilms and inhibition of biofilm formation by using the CDs has also been established. Our findings present a potential solution to combat antibacterial resistance and offer a path to reduce dependence on traditional antibiotics. Shining carbon dots (CDs) produced by a single-step hydrothermal method can afford enhanced antibacterial activity against both Gram-positive and Gram-negative bacteria. Mechanistic insights reveal that the CDs generate singlet oxygen (1O2) under light irradiation, contributing to an augmented ROS level, facilitating disruption of biofilms and inhibition of biofilm formation. image
WOS关键词SALMONELLA-TYPHIMURIUM ; STAPHYLOCOCCUS-AUREUS ; QUANTUM DOTS ; OXYGEN ; NANOPARTICLES ; RESISTANCE ; FILMS
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:001232562300001
资助机构National Natural-Science Foundation of China ; Special Fund for the Qingdao Science and Technology Program of Public Wellbeing
源URL[http://ir.yic.ac.cn/handle/133337/35647]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Xuan, Guanhua; Wang, Guoqing
作者单位1.Ningbo Univ, Coll Marine Sci, Ningbo, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
4.Ocean Univ China, Coll Food Sci & Engn, State Key Lab Marine Food Proc & Safety Control, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Qingsong,Fu, Jianxin,Lin, Hong,et al. Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption[J]. BIOTECHNOLOGY JOURNAL,2024,19(5):11.
APA Zhang, Qingsong.,Fu, Jianxin.,Lin, Hong.,Xuan, Guanhua.,Zhang, Weiwei.,...&Wang, Guoqing.(2024).Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption.BIOTECHNOLOGY JOURNAL,19(5),11.
MLA Zhang, Qingsong,et al."Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption".BIOTECHNOLOGY JOURNAL 19.5(2024):11.

入库方式： OAI收割

来源：烟台海岸带研究所

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