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Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma

文献类型：期刊论文

作者Lv, Bingqian4; Wang, Yunqing3; Mei, Rongchao2; Li, Yan4; Zhao, Xizhen1,3; Yuan, Qi1,3; Xu, Hui4; Chen, Lingxin3,5
刊名ACS APPLIED NANO MATERIALS
出版日期2024-06-14
卷号7期号:12页码:14665-14672
关键词superhydrophobic substrate surface-enhanced Raman spectroscopy 3D hotspot blood drug detection portableRaman spectrometer
DOI10.1021/acsanm.4c02202
通讯作者Wang, Yunqing(yqwang@yic.ac.cn) ; Xu, Hui(xuhui@ytu.edu.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要In situ, fast, sensitive detection of drugs in blood is in great demand in many clinical scenarios. Surface-enhanced Raman spectroscopy (SERS) has shown great potential in drug analysis; however, achieving highly sensitive detection using a portable Raman instrument is still challenging. Herein, a superhydrophobic silver-film-assisted 3D SERS platform was proposed for sensitive detection of drugs in plasma. The superhydrophobic silver film was prepared through the self-assembly of silver nanoparticles (Ag NPs) at the liquid-liquid interface. Gold-silver core-shell (Au@Ag) nanoparticles (NPs), encoded with an internal standard signal, were mixed with the plasma sample. The mixture formed nanocomposites on the superhydrophobic silver film, creating abundant 3D hotspots that greatly enhanced the signal of the analytes. The 3D platform enabled the detection of crystal violet as low as 10(-13) M, and a relative standard deviation (RSD) of 13.4% using a research-grade Raman spectrometer. Furthermore, mitoxantrone and methylene blue drug analysis in plasma was performed by using a portable Raman spectrometer, which could be detected at as low as 8 x 10(-10) and 3 x 10(-8) M, respectively, with an improved signal repeatability (RSD 2.5%). Based on this technique, the pharmacokinetics of the two drugs postintravenous injection in mice was investigated. This work provided a facile and sensitive protocol for plasma drug analysis, showing great promise for the popularization of portable Raman spectroscopy in real clinical applications.
WOS关键词SURFACE ; MITOXANTRONE ; SILVER ; PHARMACOKINETICS
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001248677200001
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Special Fund for Leading Scholar Program of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/35911]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Wang, Yunqing; Xu, Hui; Chen, Lingxin
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
4.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Yantai 264005, Peoples R China
5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Lv, Bingqian,Wang, Yunqing,Mei, Rongchao,et al. Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma[J]. ACS APPLIED NANO MATERIALS,2024,7(12):14665-14672.
APA Lv, Bingqian.,Wang, Yunqing.,Mei, Rongchao.,Li, Yan.,Zhao, Xizhen.,...&Chen, Lingxin.(2024).Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma.ACS APPLIED NANO MATERIALS,7(12),14665-14672.
MLA Lv, Bingqian,et al."Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma".ACS APPLIED NANO MATERIALS 7.12(2024):14665-14672.

入库方式： OAI收割

来源：烟台海岸带研究所

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