Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction
文献类型：期刊论文
| 作者 | Ji, Yunxia3,5; Chen, Libang3; Wang, Yunqing4 ; Zhang, Jinjin5; Yu, Yue3; Wang, Meirong3; Wang, Xiaoyan3; Liu, Weili5; Yan, Bing2; Xiao, Liang1
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| 刊名 | ACS NANO
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| 出版日期 | 2024-06-13 |
| 页码 | 18 |
| 关键词 | nanoplastic ferroptosis ferritinophagy pulmonary toxicity mitochondrial damage |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.4c02335 |
| 通讯作者 | Song, Xiaodong(songxd71@163.com) ; Lv, Changjun(lucky_lcj@sina.com) ; Chen, Lingxin(lxchen@yic.ac.cn) |
| 英文摘要 | The smaller size fraction of plastics may be more substantially existing and detrimental than larger-sized particles. However, reports on nanoplastics (NPs), especially their airborne occurrences and potential health hazards to the respiratory system, are scarce. Previous studies limit the understanding of their real respiratory effects, since sphere-type polystyrene (PS) nanoparticles differ from NPs occurring in nature with respect to their physicochemical properties. Here, we employ a mechanical breakdown method, producing NPs directly from bulk plastic, preserving NP properties in nature. We report that among four relatively high abundance NP materials PS, polyethylene terephthalate (PET), polyvinyl chloride (PVC), and polyethylene (PE) with a size of 100 nm, PVC induced slightly more severe lung toxicity profiles compared to the other plastics. The lung cytotoxicity of NPs is higher than that of commercial PS NPs and comparable to natural particles silicon dioxide (SiO2) and anatase titanium dioxide (TiO2). Mechanistically, BH3-interacting domain death agonist (Bid) transactivation-mediated mitochondrial dysfunction and nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy or ferroptosis are likely common mechanisms of NPs regardless of their chemical composition. This study provides relatively comprehensive data for evaluating the risk of atmospheric NPs to lung health. |
| WOS关键词 | CELL-DEATH ; FERROPTOSIS ; AUTOPHAGY ; OXIDATION ; RECEPTOR |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001247376200001 |
| 资助机构 | National Nature Science Foundation of China ; Introduced Innovative R&D Team Project under the The Pearl River Talent Recruitment Program of Guangdong Province ; Natural Science Foundation of Shandong Province ; Start-up Fund for Doctoral Research Program ; Science and Technology Plan Project of Binzhou Medical University ; Regenerative Medicine Research Program of Xu Rongxiang ; The 2023 National Key R&D Plan of the Ministry of Science and Technology Sino US International Cooperation Project ; Taishan Scholar Project Special Funding ; Shandong Province University Youth Innovation Team Project |
| 源URL | [http://ir.yic.ac.cn/handle/133337/35938]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 烟台海岸带研究所_山东省海岸带环境工程技术研究中心 |
| 通讯作者 | Song, Xiaodong; Lv, Changjun; Chen, Lingxin |
| 作者单位 | 1.Naval Med Univ, Mil Med Univ 2, Fac Naval Med, Shanghai 200433, Peoples R China 2.Guangzhou Univ, Inst Environm Res Greater Bay Area, Key Lab Water Qual & Conservat Pearl River Delta, Minist Educ, Guangzhou 510006, Peoples R China 3.Binzhou Med Univ, Sch Pharmaceut Sci, Dept Cellular & Genet Med, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 5.Binzhou Med Univ, Binzhou Med Univ Hosp, Dept Resp & Crit Care Med, Binzhou 256603, Peoples R China 6.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Yunxia,Chen, Libang,Wang, Yunqing,et al. Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction[J]. ACS NANO,2024:18. |
| APA | Ji, Yunxia.,Chen, Libang.,Wang, Yunqing.,Zhang, Jinjin.,Yu, Yue.,...&Chen, Lingxin.(2024).Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction.ACS NANO,18. |
| MLA | Ji, Yunxia,et al."Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction".ACS NANO (2024):18. |
入库方式： OAI收割
来源：烟台海岸带研究所
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