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  4. 中科院海岸带环境过程与生态修复重点实验室
Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium

文献类型：期刊论文

作者Zhan, Junfei2; Song, Changlin1,3,4; Wang, Zhiyu1,3,5; Wu, Huifeng1,3; Ji, Chenglong1,3
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2024-06-25
卷号931页码:8
关键词Benchmark dose Cadmium Dose-response relationship Low salinity Pacific oyster
ISSN号0048-9697
DOI10.1016/j.scitotenv.2024.172919
通讯作者Ji, Chenglong(clji@yic.ac.cn)
英文摘要Species in estuaries tend to undergo both cadmium (Cd) and low salinity stress. However, how low salinity affects the Cd toxicity has not been fully understood. Investigating the impacts of low salinity on the doseresponse relationships between Cd and biological endpoints has potential to enhance our understanding of the combined effects of low salinity and Cd. In this work, changes in the transcriptomes of Pacific oysters were analyzed following exposure to Cd (5, 20, 80 mu g/L Cd2+) under normal (31.4 psu) and low (15.7 psu) salinity conditions, and then the dose-response relationship between Cd and transcriptome was characterized in a highthroughput manner. The benchmark dose (BMD) of gene expression, as a point of departure (POD), was also calculated based on the fitted dose-response model. We found that low salinity treatment significantly influenced the dose-response relationships between Cd and transcripts in oysters indicated by altered dose-response curves. In details, a total of 219 DEGs were commonly fitted to best models under both normal and low salinity conditions. Nearly three quarters of dose-response curves varied with salinity condition. Some monotonic doseresponse curves in normal salinity condition even were replaced by nonmonotonic curves in low salinity condition. Low salinity treatment decreased the PODs of differentially expressed genes induced by Cd, suggesting
WOS关键词METAL POLLUTION ; HORMESIS ; TOXICOLOGY
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001239510300001
资助机构National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation, China ; Fundamental Research Projects of Science and Technology Innovation and Development Plan in Yantai City
源URL[http://ir.yic.ac.cn/handle/133337/35950]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_近岸生态与环境实验室
通讯作者Ji, Chenglong
作者单位1.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
2.Ludong Univ, Key Lab Ecol Restorat & Conservat Coastal Wetlands, Inst Adv Study Coastal Ecol, Yantai 264025, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714		 Zhan, Junfei,Song, Changlin,Wang, Zhiyu,et al. Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,931:8.
APA Zhan, Junfei,Song, Changlin,Wang, Zhiyu,Wu, Huifeng,&Ji, Chenglong.(2024).Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium.SCIENCE OF THE TOTAL ENVIRONMENT,931,8.
MLA Zhan, Junfei,et al."Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium".SCIENCE OF THE TOTAL ENVIRONMENT 931(2024):8.

入库方式： OAI收割

来源：烟台海岸带研究所

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