Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography
文献类型：期刊论文
| 作者 | Wu, Wenpu1; Yu, Cuichi1; Sui, Lei1; Xu, Hui1; Li, Jinhua3 ; Zhou, Na3; Chen, Lingxin2,3; Song, Zhihua1
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| 刊名 | ANALYST
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| 出版日期 | 2024-05-31 |
| 页码 | 8 |
| ISSN号 | 0003-2654 |
| DOI | 10.1039/d4an00239c |
| 通讯作者 | Xu, Hui(xuhui33@sina.com) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Song, Zhihua(zhihuasong@yeah.net) |
| 英文摘要 | Molecularly imprinted polymer (MIP)-based chromatographic separation materials, owing to their advantages of unique selectivity, low cost, suitable reproducibility, and acceptable stability, have attracted a great deal of research in different fields. In this investigation, a new type of MIP-coated silica (MIP/SiO2) separation material was developed using sulfamethoxazole as a template; the specific recognition ability of MIP and appropriate physicochemical properties (abundant Si-OH, suitable pore structure, good stability, etc.) of SiO2 microbeads were combined. The MIP/SiO2 separation materials were characterized carefully. Then, various compounds (such as sulfonamides, ginsenosides, nucleosides, and several pesticides) were used to comprehensively evaluate the chromatographic performances of the MIP/SiO2 column. Furthermore, the chromatographic performances of the MIP/SiO2 column were compared with those of other separation materials (such as non-imprinted polymer-coated silica, C18/SiO2, and bare silica) packed columns. The resolution value of all measured compounds was more than 1.51. The column efficiencies of 13 510 plates per meter (N m-1) for sulfamethoxazole, 11 600 N m-1 for ginsenoside Rd, and 10 510 N m-1 for 2 '-deoxyadenosine were obtained. The acceptable results verified that the MIP/SiO2 column can be applied to separate highly polar drugs such as sulfonamides, ginsenosides, nucleosides, and pesticides. Molecularly imprinted polymer-based chromatographic separation materials, owing to their advantages of unique selectivity, low cost, suitable reproducibility, and acceptable stability, have attracted a great deal of research in different fields. |
| WOS关键词 | SEPARATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001241905600001 |
| 资助机构 | Yantai Science and Technology Bureau ; Science and Technology Innovation Development Plan of Yantai City of China ; Yantai University Student Innovation and Entrepreneurship Training Program |
| 源URL | [http://ir.yic.ac.cn/handle/133337/35953]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 烟台海岸带研究所_山东省海岸带环境工程技术研究中心 |
| 通讯作者 | Xu, Hui; Chen, Lingxin; Song, Zhihua |
| 作者单位 | 1.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Yantai 264005, Peoples R China 2.Binzhou Med Coll, Sch Pharm, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat,, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Wenpu,Yu, Cuichi,Sui, Lei,et al. Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography[J]. ANALYST,2024:8. |
| APA | Wu, Wenpu.,Yu, Cuichi.,Sui, Lei.,Xu, Hui.,Li, Jinhua.,...&Song, Zhihua.(2024).Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography.ANALYST,8. |
| MLA | Wu, Wenpu,et al."Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography".ANALYST (2024):8. |
入库方式： OAI收割
来源：烟台海岸带研究所
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