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  4. 中科院海岸带环境过程与生态修复重点实验室
Insights into the discovery and intervention of metalloproteinase in marine hazardous jellyfish

文献类型：期刊论文

作者Yang, Fengling4,5; Yang, Kai4,5; Wang, Yi4,5; Yao, Jinchi1,5; Hua, Xiaoyu5; Danso, Blessing5; Wang, Yongfang5; Liang, Hongyu4,5; Wang, Mingke2; Chen, Jingbo5
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2024-07-05
卷号472页码:12
关键词Chrysaora quinquecirrha Jellyfish Metalloproteinase Toxin Tetracycline hydrochloride
ISSN号0304-3894
DOI10.1016/j.jhazmat.2024.134526
通讯作者Chen, Lingxin(lxchen@yic.ac.cn) ; Xiao, Liang(hormat830713@hotmail.com) ; Zhang, Jing(zhjing0701@163.com)
英文摘要The proliferation of toxic organisms caused by changes in the marine environment, coupled with the rising human activities along the coastal lines, has resulted in an increasing number of stinging incidents, posing a serious threat to public health. Here, we evaluated the systemic toxicity of the venom in jellyfish Chrysaora quinquecirrha at both cellular and animal levels, and found that jellyfish tentacle extract (TE) has strong lethality accompanied by abnormal elevation of blood biochemical indicators and pathological changes. Joint analysis of transcriptome and proteome indicated that metalloproteinases are the predominant toxins in jellyfish. Specially, two key metalloproteinases DN6695_c0_g3 and DN8184_c0_g7 were identified by mass spectrometry of the red blood cell membrane and tetracycline hydrochloride (Tch) inhibition models. Structurally, molecular docking and kinetic analysis are employed and observed that Tch could inhibit the enzyme activity by binding to the hydrophobic pocket of the catalytic center. In this study, we demonstrated that Tch impedes the metalloproteinase activity thereby reducing the lethal effect of jellyfish, which suggests a potential strategy for combating the health threat of marine toxic jellyfish.
WOS关键词MATRIX ; PROTEINS ; FAMILY ; BLOOMS
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001237991000001
资助机构National Key R & D Plan of the Ministry of Science and Technology Sino US International Cooperation Project ; National Natural Science Foundation of China
源URL[http://ir.yic.ac.cn/handle/133337/35959]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Chen, Lingxin; Xiao, Liang; Zhang, Jing
作者单位1.Liaoning Normal Univ, Sch Life Sci, Dalian 116081, Peoples R China
2.Naval Med Univ, Med Care Ctr, Naval Med Ctr PLA, Shanghai 200052, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
4.Jilin Agr Univ, Coll Tradit Chinese Med, Changchun 130118, Peoples R China
5.Naval Med Univ, Mil Med Univ 2, Fac Naval Med, Shanghai 200433, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Fengling,Yang, Kai,Wang, Yi,et al. Insights into the discovery and intervention of metalloproteinase in marine hazardous jellyfish[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,472:12.
APA Yang, Fengling.,Yang, Kai.,Wang, Yi.,Yao, Jinchi.,Hua, Xiaoyu.,...&Zhang, Jing.(2024).Insights into the discovery and intervention of metalloproteinase in marine hazardous jellyfish.JOURNAL OF HAZARDOUS MATERIALS,472,12.
MLA Yang, Fengling,et al."Insights into the discovery and intervention of metalloproteinase in marine hazardous jellyfish".JOURNAL OF HAZARDOUS MATERIALS 472(2024):12.

入库方式： OAI收割

来源：烟台海岸带研究所

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