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Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection

文献类型：期刊论文

作者Wang, Junhao4,5,6; Zhou, Huihui1; Liang, Rongning4,6; Qin, Wei2,3,4,6
刊名ANALYTICAL CHEMISTRY
出版日期2024-04-29
卷号96期号:23页码:9370-9378
ISSN号0003-2700
DOI10.1021/acs.analchem.3c05817
通讯作者Liang, Rongning(rnliang@yic.ac.cn) ; Qin, Wei(wqin@yic.ac.cn)
英文摘要The development of sensors for detection of biomarkers exhibits an exciting potential in diagnosis of diseases. Herein, we propose a novel electrochemical sensing strategy for label-free dual-biomarker detection, which is based on the combination of stimulus-responsive molecularly imprinted polymer (MIP)-modified nanopores and a polymeric membrane chronopotentiometric sensor. The ion fluxes galvanostatically imposed on the sensing membrane surface can be blocked by the recognition reaction between the target biomarker in the sample solution and the stimulus-responsive MIP receptor in the nanopores, thus causing a potential change. By using two external stimuli (i.e., pH and temperature), the recognition abilities of the stimulus-responsive MIP receptor can be effectively modulated so that dual-biomarker label-free chronopotentiometric detection can be achieved. Using alpha fetoprotein (AFP) and prostate-specific antigen (PSA) as model biomarkers, the proposed sensor offers detection limits of 0.17 and 0.42 ng/mL for AFP and PSA, respectively.
WOS关键词DETECTION LIMIT ; MEMBRANE ELECTRODES ; ION FLUXES ; SURFACE ; GLYCOPROTEINS ; RECOGNITION ; MODULATION ; NANOSENSOR ; BIOSENSOR ; ANTIGEN
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001241271300001
资助机构Key Technology Research and Development Program of Shandong Province ; National Natural Science Foundation of China ; Key R&D Program of Shandong Province ; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences ; Taishan Scholar Program of Shandong Province
源URL[http://ir.yic.ac.cn/handle/133337/35971]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_近岸生态与环境实验室
通讯作者Liang, Rongning; Qin, Wei
作者单位1.Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Yantai 264099, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
4.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Junhao,Zhou, Huihui,Liang, Rongning,et al. Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection[J]. ANALYTICAL CHEMISTRY,2024,96(23):9370-9378.
APA Wang, Junhao,Zhou, Huihui,Liang, Rongning,&Qin, Wei.(2024).Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection.ANALYTICAL CHEMISTRY,96(23),9370-9378.
MLA Wang, Junhao,et al."Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection".ANALYTICAL CHEMISTRY 96.23(2024):9370-9378.

入库方式： OAI收割

来源：烟台海岸带研究所

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