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Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique

文献类型：期刊论文

作者Tan, Mingyue5; Wang, Yunqing1; Ji, Yunxia5; Mei, Rongchao5; Zhao, Xizhen1,4; Song, Jie5; You, Jinmao2; Chen, Lingxin1,2,3; Wang, Xiaoyan5
刊名TALANTA
出版日期2024-08-01
卷号275页码:9
关键词Surface-enhanced Raman scattering SERS tag Inflammatory bowel disease Nanoparticles In vivo
ISSN号0039-9140
DOI10.1016/j.talanta.2024.126172
通讯作者Wang, Yunqing(yqwang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Wang, Xiaoyan(wangxy@yic.ac.cn)
英文摘要Nanoparticles (NPs) could be uptake orally and exposed to digestive tract through various sources such as particulate pollutant, nanomedicine and food additive. Inflammatory bowel disease (IBD), as a global disease, induced disruption of the intestinal mucosal barrier and thus altered in vivo distribution of NPs as a possible consequence. However, related information was relatively scarce. Herein, in vivo distribution of typical silica (SiO 2 ) and titania (TiO 2 ) NPs was investigated in healthy and IBD models at cell and animal levels via a surfaceenhanced Raman scattering (SERS) tag labeling technique. The labeled NPs were composed of gold SERS tag core and SiO 2 (or TiO 2 ) shell, demonstrating sensitive and characteristic SERS signals ideal to trace the NPs in vivo . Cell SERS mapping revealed that protein corona from IBD intestinal fluid decreased uptake of NPs by lipopolysaccharide-induced RAW264.7 cells compared with normal intestinal fluid protein corona. SERS signal detection combined with inductively coupled plasma mass spectrometry (ICP-MS) analysis of mouse tissues (heart, liver, spleen, lung and kidney) indicated that both NPs tended to accumulate in lung specifically after oral administration for IBD mouse (6 out of 20 mice for SiO 2 and 4 out of 16 mice for TiO 2 were detected in lung). Comparatively, no NP signals were detected in all tissues from healthy mice. These findings suggested that there might be a greater risk associated with the oral uptake of NPs in IBD patients due to altered in vivo distribution of NPs.
WOS关键词M-CELLS ; EPIDEMIOLOGY ; ABSORPTION ; INTESTINE ; TRANSPORT
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001235885700001
资助机构Foundation of China ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Special Fund for Leading Scholar Program of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/35980]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Wang, Yunqing; Chen, Lingxin; Wang, Xiaoyan
作者单位1.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China
3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Mingyue,Wang, Yunqing,Ji, Yunxia,et al. Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique[J]. TALANTA,2024,275:9.
APA Tan, Mingyue.,Wang, Yunqing.,Ji, Yunxia.,Mei, Rongchao.,Zhao, Xizhen.,...&Wang, Xiaoyan.(2024).Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique.TALANTA,275,9.
MLA Tan, Mingyue,et al."Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique".TALANTA 275(2024):9.

入库方式： OAI收割

来源：烟台海岸带研究所

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