Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment
文献类型：期刊论文
| 作者 | Sun, Tao2,3,4; Ji, Chenglong1,2,3,5 ; Li, Fei1,2,3; Wu, Huifeng1,2,3,5
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2024-05-06 |
| 卷号 | 58期号:21页码:9314-9327 |
| 关键词 | per- and polyfluoroalkyl substances (PFAS) risk assessment subthreshold effect hormesis biological plasticity |
| ISSN号 | 0013-936X |
| DOI | 10.1021/acs.est.4c00686 |
| 通讯作者 | Wu, Huifeng(hfwu@yic.ac.cn) |
| 英文摘要 | Globally implemented ecological risk assessment (ERA) guidelines marginalize hormesis, a biphasic dose-response relationship characterized by low-dose stimulation and high-dose inhibition. The present study illuminated the promise of hormesis as a scientific dose-response model for ERA of per- and polyfluoroalkyl substances (PFAS) represented by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). A total of 266 hormetic dose-response relationships were recompiled from 1237 observations, covering 30 species from nine representative taxonomic groups. The standardized hormetic amplitudes followed the log-normal probability distribution, being subject to the limits of biological plasticity but independent of stress inducers. The SHapley Additive exPlanations algorithm revealed that the target endpoint was the most important variable explaining the hormetic amplitudes. Subsequently, quantitative frameworks were established to incorporate hormesis into the predicted no-effect concentration levels, with a lower induction dose and a zero-equivalent point but a broader hormetic zone for PFOS. Realistically, 10,117 observed concentrations of PFOA and PFOS were gathered worldwide, 4% of which fell within hormetic zones, highlighting the environmental relevance of hormesis. Additionally, the hormesis induction potential was identified in other legacy and emerging PFAS as well as their alternatives and mixtures. Collectively, it is time to incorporate the hormesis concept into PFAS studies to facilitate more realistic risk characterizations. |
| WOS关键词 | HORMETIC DOSE RESPONSES ; PERFLUOROOCTANE SULFONATE ; SURFACE-WATER ; TOXICITY ; PFOA ; METAANALYSIS ; HOMEOSTASIS ; EXPOSURE ; DAMAGE ; PFASS |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001225120100001 |
| 资助机构 | Key Technology Research and Development Program of Shandong Province ; Key R&D Program of Shandong Province, China ; National Natural Science Foundation of China ; Young Taishan Scholars Program of Shandong Province |
| 源URL | [http://ir.yic.ac.cn/handle/133337/36047]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 烟台海岸带研究所_近岸生态与环境实验室 |
| 通讯作者 | Wu, Huifeng |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Laoshan Lab, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Tao,Ji, Chenglong,Li, Fei,et al. Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2024,58(21):9314-9327. |
| APA | Sun, Tao,Ji, Chenglong,Li, Fei,&Wu, Huifeng.(2024).Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment.ENVIRONMENTAL SCIENCE & TECHNOLOGY,58(21),9314-9327. |
| MLA | Sun, Tao,et al."Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment".ENVIRONMENTAL SCIENCE & TECHNOLOGY 58.21(2024):9314-9327. |
入库方式： OAI收割
来源：烟台海岸带研究所
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