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Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid

文献类型：期刊论文

作者Li, Yan3,4; Wang, Yunqing3; Mei, Rongchao1; Lv, Bingqian4; Zhao, Xizhen5; Bi, Liyan1; Xu, Hui4; Chen, Lingxin2,3
刊名ACS SENSORS
出版日期2024-05-02
卷号9期号:5页码:2567-2574
关键词surface-enhanced Raman spectroscopy microneedles interstitial fluid drug detection point-of-caretesting
ISSN号2379-3694
DOI10.1021/acssensors.4c00276
通讯作者Wang, Yunqing(yqwang@yic.ac.cn) ; Xu, Hui(xuhui@ytu.edu.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要In vivo drug monitoring is crucial for evaluating the effectiveness and safety of drug treatment. Blood sampling and analysis is the current gold standard but needs professional skills and cannot meet the requirements of point-of-care testing. Dermal interstitial fluid (ISF) showed great potential to replace blood for in vivo drug monitoring; however, the detection was challenging, and the drug distribution behavior in ISF was still unclear until now. In this study, we proposed surface-enhanced Raman spectroscopy (SERS) microneedles (MNs) for the painless and real-time analysis of drugs in ISF after intravenous injection. Using methylene blue (MB) and mitoxantrone (MTO) as model drugs, the innovative core-satellite structured Au@Ag SERS substrate, hydrogel coating over the MNs, rendered sensitive and quantitative drug detection in ISF of mice within 10 min. Based on this technique, the pharmacokinetics of the two drugs in ISF was investigated and compared with those in blood, where the drugs were analyzed via liquid chromatography-mass spectrometry. It was found that the MB concentration in ISF and blood was comparable, whereas the concentration of MTO in ISF was 2-3 orders of magnitude lower than in blood. This work proposed an efficient tool for ISF drug monitoring. More importantly, it experimentally proved that the penetration ratio of blood to ISF was drug-dependent, providing insightful information into the potential of ISF as a blood alternative for in vivo drug detection.
WOS关键词QUANTIFICATION
WOS研究方向Chemistry ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:001225416200001
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Shandong Science and Technology Foundation ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Special Fund for Leading Scholar Program of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/36050]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Wang, Yunqing; Xu, Hui; Chen, Lingxin
作者单位1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
4.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Yantai 264005, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yan,Wang, Yunqing,Mei, Rongchao,et al. Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid[J]. ACS SENSORS,2024,9(5):2567-2574.
APA Li, Yan.,Wang, Yunqing.,Mei, Rongchao.,Lv, Bingqian.,Zhao, Xizhen.,...&Chen, Lingxin.(2024).Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid.ACS SENSORS,9(5),2567-2574.
MLA Li, Yan,et al."Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid".ACS SENSORS 9.5(2024):2567-2574.

入库方式： OAI收割

来源：烟台海岸带研究所

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