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  4. 中科院海岸带环境过程与生态修复重点实验室
Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe

文献类型：期刊论文

作者Wang, Lingxiao4; Wang, Lingyun2; Sun, Xiao4; Fu, Lili1,4; Sun, Mingzhao4; Wang, Xinlei4; Wang, Xiaoyan1,4; Chen, Lingxin1,3,5; Huang, Yan4
刊名SENSORS AND ACTUATORS B-CHEMICAL
出版日期2024-06-15
卷号409页码:9
关键词Carboxylesterase 2 Fluorescent probe Colitis Colon cancer Chemotherapy resistance
DOI10.1016/j.snb.2024.135609
通讯作者Chen, Lingxin(lxchen@yic.ac.cn) ; Huang, Yan(yhuang@yic.ac.cn)
英文摘要Colitis is one of the important etiologies of colon cancer, but the diagnosis of early colitis and colon cancer is still a difficult problem, so it is important to use reasonable methods to achieve the diagnosis of early colitis and colon cancer. Carboxylesterase 2 (CES2) is momentous in the development of colon disease and can be used as an indicator to distinguish colitis from colon cancer. CES2 is expressed differently in colitis and colon cancer, so it has the potential to distinguish colitis from colon cancer by detecting the difference in CES2 expression. We designed a fluorescent probe Bcy-CES2 for imaging CES2 in cells and in vivo and evaluating the differences in CES2 levels in colon disease. Probe Bcy-CES2 shows good potential for in situ real -time monitoring of endogenous CES2. In addition, we found that the combination of CES2 inhibitor BNPP and cisplatin can reduce tumor chemotherapy resistance, and CES2 levels may become a new index for early diagnosis and prognosis of colon cancer.
WOS关键词COLORECTAL-CANCER ; CHEMORESISTANCE ; CELLS
WOS研究方向Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种英语
WOS记录号WOS:001211466100001
资助机构National Nature Science Foundation of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization
源URL[http://ir.yic.ac.cn/handle/133337/36090]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Chen, Lingxin; Huang, Yan
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Jinan Zhangqiu Dist Peoples Hosp, Jinan 250000, Peoples R China
3.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China
4.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
5.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Lingxiao,Wang, Lingyun,Sun, Xiao,et al. Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe[J]. SENSORS AND ACTUATORS B-CHEMICAL,2024,409:9.
APA Wang, Lingxiao.,Wang, Lingyun.,Sun, Xiao.,Fu, Lili.,Sun, Mingzhao.,...&Huang, Yan.(2024).Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe.SENSORS AND ACTUATORS B-CHEMICAL,409,9.
MLA Wang, Lingxiao,et al."Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe".SENSORS AND ACTUATORS B-CHEMICAL 409(2024):9.

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来源：烟台海岸带研究所

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