New Near-Infrared Fluorescence Imaging Platform with Large Stokes Shift for Carboxylesterase 2 Detection in Thyroid Cancer and Inflammatory Diseases Diagnosis
文献类型：期刊论文
| 作者 | Wang, Xiaochun2,3; Gao, Jian2; Fan, Chuanfeng2; Gao, Yingkai2; Yang, Xintong2; Chen, Lingxin1,4,5
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| 刊名 | ANALYTICAL CHEMISTRY
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| 出版日期 | 2024-02-19 |
| 卷号 | 96期号:9页码:3772-3779 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.3c04399 |
| 通讯作者 | Wang, Xiaochun(wangwxc@qust.edu.cn) |
| 英文摘要 | Development of new near-infrared fluorophores is one of the eternal themes in the field of biosensing and biological imaging. In this work, we constructed a novel fluorophore platform MOR by replacing methylindole of hemicyanine fluorophore (CyR) with benzoxazole to acquire better fluorescence characteristics. Based on the platform, a near infrared (NIR) fluorescent probe MOR-CES2 was synthesized for the specific "off-on" response to carboxylesterase 2 (CES2). The probe exhibited excellent properties including near-infrared emission (735 nm), large Stokes shift (105 nm), high sensitivity (LOD, 0.3 ng/mL), and rapid response (15 min). The successful application of MOR-CES2 in biological imaging of CES2 in mice with thyroid cancer and inflammatory bowel disease demonstrated that the probe could identify cancer cells and tissues and sensitively respond to inflammation. The results proved the potency of MOR-CES2 as an efficient imaging tool to assist in the surgical resection of CES2-related tumors. |
| WOS关键词 | CATALYTIC-PROPERTIES ; LIVING CELLS ; PROBE ; ACTIVATION ; EXPRESSION ; ISOZYMES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001166901900001 |
| 资助机构 | National Natural Science Foundation of China ; Start-Up Fund of Qingdao University of Science and Technology |
| 源URL | [http://ir.yic.ac.cn/handle/133337/36320]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 烟台海岸带研究所_山东省海岸带环境工程技术研究中心 |
| 通讯作者 | Wang, Xiaochun |
| 作者单位 | 1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 2.Qingdao Univ Sci & Technol, Key Lab Opt Elect Sensing & Analyt Chem Life Sci, Shandong Prov Key Lab Biochem Engn, MOE,Coll Marine Sci & Biol Engn,Qingdao Nucl Acid, Qingdao 266042, Peoples R China 3.Anshan Normal Univ, Sch Chem & Life Sci, Liaoning Key Lab Dev & Utilizat Nat Prod Act Mol, Anshan 114007, Peoples R China 4.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China 5.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res,Res Ctr Coastal Envir, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaochun,Gao, Jian,Fan, Chuanfeng,et al. New Near-Infrared Fluorescence Imaging Platform with Large Stokes Shift for Carboxylesterase 2 Detection in Thyroid Cancer and Inflammatory Diseases Diagnosis[J]. ANALYTICAL CHEMISTRY,2024,96(9):3772-3779. |
| APA | Wang, Xiaochun,Gao, Jian,Fan, Chuanfeng,Gao, Yingkai,Yang, Xintong,&Chen, Lingxin.(2024).New Near-Infrared Fluorescence Imaging Platform with Large Stokes Shift for Carboxylesterase 2 Detection in Thyroid Cancer and Inflammatory Diseases Diagnosis.ANALYTICAL CHEMISTRY,96(9),3772-3779. |
| MLA | Wang, Xiaochun,et al."New Near-Infrared Fluorescence Imaging Platform with Large Stokes Shift for Carboxylesterase 2 Detection in Thyroid Cancer and Inflammatory Diseases Diagnosis".ANALYTICAL CHEMISTRY 96.9(2024):3772-3779. |
入库方式： OAI收割
来源：烟台海岸带研究所
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