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  4. 海岸带生物学与生物资源利用重点实验室
Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides

文献类型：期刊论文

作者Ye, Zifan1; Fu, Lei3; Li, Shuangyu1; Chen, Ziying3; Ouyang, Jianhong1; Shang, Xinci1; Liu, Yanli1; Gao, Lianghui3; Wang, Yipeng1,2
刊名NATURE COMMUNICATIONS
出版日期2024-08-25
卷号15期号:1页码:26
DOI10.1038/s41467-024-51730-x
通讯作者Gao, Lianghui(lhgao@bnu.edu.cn) ; Wang, Yipeng(yipengwang@suda.edu.cn)
英文摘要Non-direct antimicrobial cationic peptides (NDACPs) are components of the animal innate immune system. But their functions and association with antimicrobial peptides (AMPs) are incompletely understood. Here, we reveal a synergistic interaction between the AMP AW1 and the NDACP AW2, which are co-expressed in the frog Amolops wuyiensis. AW2 enhances the antibacterial activity of AW1 both in vitro and in vivo, while mitigating the development of bacterial resistance and eradicating biofilms. AW1 and AW2 synergistically damage bacterial membranes, facilitating cellular uptake and interaction of AW2 with the intracellular target bacterial genomic DNA. Simultaneously, they trigger the generation of ROS in bacteria, contributing to cell death upon reaching a threshold level. Moreover, we demonstrate that this synergistic antibacterial effect between AMPs and NDACPs is prevalent across diverse animal species. These findings unveil a robust and previously unknown correlation between AMPs and NDACPs as a widespread antibacterial immune defense strategy in animals. Antimicrobial peptides and non-direct antimicrobial cationic peptides are secreted in response to invasive pathogens. Here, Ye et al show that there is a synergistic interaction between these two types of expressed peptides from the amphibian frog Amolops wuyiensis.
WOS关键词ESCHERICHIA-COLI ; ANTIBIOTIC-RESISTANCE ; KLEBSIELLA-PNEUMONIAE ; SYNTHETIC PEPTIDE ; BIOFILM FORMATION ; OXIDATIVE STRESS ; SKIN ; CELL ; CATHELICIDINS ; IDENTIFICATION
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001298087400008
资助机构National Natural Science Foundation of China (National Science Foundation of China) ; National Natural Science Foundation of China ; Key Research & Development Plan in Social Development of Jiangsu Province ; Suzhou Agricultural Science and Technology Innovation Project ; Guizhou Provincial Science and Technology Projects ; Qiankehe Support [2021] General ; Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases ; Priority Academic Program Development of the Jiangsu Higher Education Institutes (PAPD)
源URL[http://ir.yic.ac.cn/handle/133337/35800]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Gao, Lianghui; Wang, Yipeng
作者单位1.Soochow Univ, Coll Pharmaceut Sci, Dept Biopharmaceut Sci, Suzhou, Jiangsu, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China
3.Beijing Normal Univ, Coll Chem, Key Lab Theoret & Computat Photochem, Minist Educ, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Zifan,Fu, Lei,Li, Shuangyu,et al. Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides[J]. NATURE COMMUNICATIONS,2024,15(1):26.
APA Ye, Zifan.,Fu, Lei.,Li, Shuangyu.,Chen, Ziying.,Ouyang, Jianhong.,...&Wang, Yipeng.(2024).Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides.NATURE COMMUNICATIONS,15(1),26.
MLA Ye, Zifan,et al."Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides".NATURE COMMUNICATIONS 15.1(2024):26.

入库方式： OAI收割

来源：烟台海岸带研究所

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