The ameliorative and neuroprotective effects of dietary fibre on hyperuricaemia mice: a perspective from microbiome and metabolome
文献类型：期刊论文
| 作者 | Wang, Yu1,2; Miao, Fengping2 ; Wang, Jun1,2; Zheng, Maokun4; Yu, Feng3; Yi, Yuetao2,5
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| 刊名 | BRITISH JOURNAL OF NUTRITION
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| 出版日期 | 2024-06-03 |
| 页码 | 14 |
| 关键词 | Hyperuricaemia Dietary fibre Microbiome Metabolome Anxiety |
| ISSN号 | 0007-1145 |
| DOI | 10.1017/S0007114524001211 |
| 通讯作者 | Yi, Yuetao(ytyi@yic.ac.cn) |
| 英文摘要 | The effect of single dietary fibre (DF) on lowering uric acid (UA) level has been reported in the literature. However, the potential protective mechanism of DF against potassium oxybate-induced hyperuricaemia (HUA), as modelled by prophylactic administration, remains unclear. The data demonstrate that DF significantly decreased serum and cerebral tissue UA concentrations, inhibited xanthine oxidase expression and activity in the liver and reduced levels of creatinine and urea nitrogen in the serum. Additionally, it mitigated the deposition of amyloid-beta in cerebral tissue. Correlation analysis showed that DF modulated the Toll-like receptor 4/NF-kappa B signalling pathway, attenuating oxidative stress and inflammatory responses in HUA mice. Additionally, DF helps to maintain the composition of the gut microbiota, reducing harmful Desulfovibrio and enriching beneficial Akkermansia and Ruminococcus populations. The results of the faecal metabolomics analysis indicate that DF facilitates the regulation of metabolic pathways involved in oxidative stress and inflammation. These pathways include pyrimidine metabolism, tryptophan metabolism, nucleotide metabolism and vitamin B6 metabolism. Additionally, the study found that DF has a preventive effect on anxiety-like behaviour induced by HUA. In summary, DF shows promise in mitigating HUA and cognitive deficits, primarily by modulating gut microbiota and metabolites. |
| WOS关键词 | SERUM URIC-ACID ; GUT MICROBIOTA ; DISEASE |
| WOS研究方向 | Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:001286278600001 |
| 资助机构 | Science & Technology Specific Projects in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta |
| 源URL | [http://ir.yic.ac.cn/handle/133337/35834]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Yi, Yuetao |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 3.Zibo Cent Hosp, Dept Gastroenterol, Zibo, Shandong, Peoples R China 4.Shandong First Med Univ & Shandong Acad Med Sci, Jinan, Peoples R China 5.Shandong Saline Alkali Land Modern Agr Co, Dongying, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yu,Miao, Fengping,Wang, Jun,et al. The ameliorative and neuroprotective effects of dietary fibre on hyperuricaemia mice: a perspective from microbiome and metabolome[J]. BRITISH JOURNAL OF NUTRITION,2024:14. |
| APA | Wang, Yu,Miao, Fengping,Wang, Jun,Zheng, Maokun,Yu, Feng,&Yi, Yuetao.(2024).The ameliorative and neuroprotective effects of dietary fibre on hyperuricaemia mice: a perspective from microbiome and metabolome.BRITISH JOURNAL OF NUTRITION,14. |
| MLA | Wang, Yu,et al."The ameliorative and neuroprotective effects of dietary fibre on hyperuricaemia mice: a perspective from microbiome and metabolome".BRITISH JOURNAL OF NUTRITION (2024):14. |
入库方式： OAI收割
来源：烟台海岸带研究所
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