Toxic effects of freshwater grouper (Acrossocheilus fasciatus) eggs on poultry: Morphological and transcriptomic insights into hepatic toxicity
文献类型：期刊论文
| 作者 | Jiang, Yanqiu1; Lu, Zhen2; Wang, Derui2,4; Hou, Zhihao2; Zhong, Tianxing1; Yan, Zhi2,3; Lin, Ainuo2; Jiang, Baozhen2; Ren, Jianfeng1; Li, Ke2
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| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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| 出版日期 | 2024-08-01 |
| 卷号 | 281页码:8 |
| 关键词 | Acrossocheilus fasciatus Egg-toxin Hepatotoxicity Differentially expressed genes |
| ISSN号 | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2024.116684 |
| 通讯作者 | Ren, Jianfeng(jfren@shou.edu.cn) ; Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | Fish egg poisoning is a serious and neglected public menace that kills hundreds of people and numerous poultry each year. Freshwater groupers (Acrossocheilus fasciatus) are common food fish in the southeastern regions of China. Their toxic eggs are regarded as a significant public health concern. The molecular mechanisms of eggtoxin toxicity in freshwater grouper to poisoned organisms are elusive. In this study, black-boned chicks were exposed to toxic eggs from freshwater grouper at a lethal dose. The hepatic morphology of the intoxicated chick was assessed. An analysis of the liver gene expression profile was conducted by comparing samples exposed to toxic eggs with control samples using RNA-Seq. The result revealed that an increase in vacuolation and congestion was observed in chicks with toxic eggs exposure. The transcriptome analysis revealed 5421 genes with differential expression, comprising 2810 up-regulated and 2611 down-regulated genes. The genes were primarily linked to energy metabolism, cell apoptosis, cell adhesion, exogenous microbial infection, and cell junction. The most strongly upregulated genes were cholecystokinin (CCK), cholecystokinin A receptor (CCKAR), and unc-80 homolog, NALCN activator (UNC80), and the most downregulated genes were glycine amidinotransferase (GATM), fatty acid desaturase 2 (FADS2), and hexokinase 2 (HKDC1). GO term with the highest enrichment of DEGs is nucleosome assembly. According to KEGG pathways, the three most significant metabolic pathways in the liver are DNA replication, retinol metabolism, and steroid biosynthesis. The results could be crucial for comprehending the negative biological impacts of egg-toxin and its toxic mechanisms. The outcome could provide potential biomarkers of egg-toxin exposure in hepatic, which might be useful for manufacturing an antidote to egg-toxin and providing valuable insights for ecotoxicity studies. |
| WOS关键词 | DEFENSE ; PREDATION |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001265938100001 |
| 资助机构 | National Natural Science Foundation of China ; National Key Research and Development Program of China ; Taishan Scholar Program from Shandong Province of China ; Yantai Municipal City's Shuangbai Plan |
| 源URL | [http://ir.yic.ac.cn/handle/133337/35849]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Ren, Jianfeng; Li, Ke |
| 作者单位 | 1.Shanghai Ocean Univ, Key Lab Freshwater Aquat Genet Resources Certifica, Minist Agr & Rural Affairs, Shanghai 210306, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China 4.Beibu Gulf Univ, Coll Marine Sci, Qinzhou 535011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Yanqiu,Lu, Zhen,Wang, Derui,et al. Toxic effects of freshwater grouper (Acrossocheilus fasciatus) eggs on poultry: Morphological and transcriptomic insights into hepatic toxicity[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2024,281:8. |
| APA | Jiang, Yanqiu.,Lu, Zhen.,Wang, Derui.,Hou, Zhihao.,Zhong, Tianxing.,...&Li, Ke.(2024).Toxic effects of freshwater grouper (Acrossocheilus fasciatus) eggs on poultry: Morphological and transcriptomic insights into hepatic toxicity.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,281,8. |
| MLA | Jiang, Yanqiu,et al."Toxic effects of freshwater grouper (Acrossocheilus fasciatus) eggs on poultry: Morphological and transcriptomic insights into hepatic toxicity".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 281(2024):8. |
入库方式： OAI收割
来源：烟台海岸带研究所
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