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  2. 烟台海岸带研究所
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  4. 海岸带生物学与生物资源利用重点实验室
Epidermal oxysterols function as alarm substances in zebrafish

文献类型：期刊论文

作者Li, Yaxi4,5; Yan, Zhi1,4; Lin, Ainuo4,5; Yang, Xiao4,5; Li, Xiaodong4; Yin, Xiuli4; Li, Weiming2; Li, Ke3,4
刊名ISCIENCE
出版日期2024-05-17
卷号27期号:5页码:16
DOI10.1016/j.isci.2024.109660
通讯作者Li, Ke(kli@yic.ac.cn)
英文摘要Alarm substances signal imminent predation thread and enable anti -predation strategies. In shoaling fish, alarm cues diffuse from injured skins that induce intense fear and anti -predation behaviors in other members. While these "fear substances"are shown to be present in numerous fishes and thought to exist in roughly 8,000 Ostariophysan species, their chemical nature remains largely unknown. We posited that fish alarm cues comprise small compounds and induce specific behaviors characteristic of fish exposed to skin extracts. Using the behaviors as bioassays, we tracked the alarm function of zebrafish skin extract to two compounds, 24-methyl-5 a- cholestane-3 a, 7 a, 12 a, 24,28-pentahydroxy 28 -sulfate, an oxysterol sulfate, and 5 a- cyprinol sulfate. At concentrations of less than one nanomolar, each compound induced antipredator behaviors and increased cortisol levels in zebrafish. Their mixture, at the natural ratio, replicated the skin extract in eliciting the full suite of anti -predator behavior patterns. Our findings reveal a molecular mechanism whereby fish escape predation danger.
WOS关键词DANIO-RERIO ; BILE-SALTS ; CHOLESTEROL-METABOLISM ; BEHAVIORAL-RESPONSES ; CYPRINOL SULFATE ; MODEL ORGANISM ; PREY ; FEAR ; QUANTIFICATION ; OSTARIOPHYSI
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001230313400001
资助机构National Natural Science Foundation of China ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Shandong Province of China ; Yantai Municipal City's Shuangbai Plan ; Great Lakes Fishery Commission
源URL[http://ir.yic.ac.cn/handle/133337/36035]  
专题海岸带生物学与生物资源利用重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Li, Ke
作者单位1.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China
2.Michigan State Univ, Dept Fisheries & Wildlife, Lansing, MI 48824 USA
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
5.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yaxi,Yan, Zhi,Lin, Ainuo,et al. Epidermal oxysterols function as alarm substances in zebrafish[J]. ISCIENCE,2024,27(5):16.
APA Li, Yaxi.,Yan, Zhi.,Lin, Ainuo.,Yang, Xiao.,Li, Xiaodong.,...&Li, Ke.(2024).Epidermal oxysterols function as alarm substances in zebrafish.ISCIENCE,27(5),16.
MLA Li, Yaxi,et al."Epidermal oxysterols function as alarm substances in zebrafish".ISCIENCE 27.5(2024):16.

入库方式： OAI收割

来源：烟台海岸带研究所

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